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Carla Brancia, Cristina Cocco, Filomena D'Amato, Barbara Noli, Fabrizio Sanna, Roberta Possenti, Antonio Argiolas, and Gian-Luca Ferri

of basic amino acid residues representing potential or demonstrated processing sites for neuroendocrine prohormone convertases, such as PC1/3 and PC2 ( Trani et al . 2002 ). In cells and tissues, proteolytic processing yields diverse peptides

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Filomena D'Amato, Barbara Noli, Carla Brancia, Cristina Cocco, Giovanna Flore, Maria Collu, Paola Nicolussi, and Gian-Luca Ferri

C-terminus. In rat brain, lower MW peptides (10, 18 and 20 kDa) were detected by an antiserum against the C-terminal VGF nonapeptide ( Trani et al . 1995 , 2002 ). Processing at the rat VGF Arg 553 -Pro 554 -Arg 555 cleavage site resulted in

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Anaies Nazarians-Armavil, Jennifer A Chalmers, Claire B Lee, Wenqing Ye, and Denise D Belsham

a number of bioactive peptides. This process is regulated by the tissue-specific expression of prohormone convertases and processing enzymes ( Pritchard et al . 2002 , Mountjoy 2010 ). Within the hypothalamus, of particular interest to metabolic

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Stamatis Varsamos, Benoît Xuereb, Thérèse Commes, Gert Flik, and Céline Spanings-Pierrot

are thus opposite to those seen in salmonids that return to FW for spawning ( Pisam & Rambourg 1991 ). Hence, an investigation into the endocrine control of the osmoregulatory processes could further our understanding of the adaptive strategy employed

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Xiaoqin Shi, Xinyu Li, Yi Hou, Xuemei Cao, Yuyao Zhang, Heng Wang, Hongyin Wang, Chuan Peng, Jibin Li, Qifu Li, Chaodong Wu, and Xiaoqiu Xiao

offspring. Detrimental impacts of maternal obesity or diabetes during perinatal periods on adiposity and metabolic function in offspring are well established, whereas the contribution of obese or diabetic fathers to these processes is poorly described. In

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S-Y Chan, J A Franklyn, H N Pemberton, J N Bulmer, T J Visser, C J McCabe, and M D Kilby

potentially modulate thyroid hormone action at a tissue level. These include deiodination of the prohormone T4 to the receptor-binding ligand T3, and the expression of functional thyroid hormone receptor isoforms. The availability of T3 for local receptor

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Peggy Schwarz, Pavel Strnad, Nadine Singer, Franz Oswald, Robert Ehehalt, Guido Adler, and Hasan Kulaksiz

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin . Blood Cells, Molecules, and Diseases 40 132 – 138 . Vyoral D Petrak J 2005 Hepcidin: a direct link between iron metabolism and immunity

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Christopher J Charles, Takeshi Katafuchi, Timothy G Yandle, and Naoto Minamino

no typical prohormone convertase processing site on either end of the deduced mature peptides, the precursor of caprine CRSP-2 has a typical prohormone convertase processing site between the N-terminal flanking peptide and the deduced mature CRSP-2

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Francisco J Arjona, Luis Vargas-Chacoff, María P Martín del Río, Gert Flik, Juan M Mancera, and Peter H M Klaren

conditions, the piscine thyroid gland mainly secretes the prohormone 3,5,3′,5′-tetraiodothyronine (T 4 ). T 4 must be converted, by removal of an iodine atom, to yield the biologically active hormone 3,5,3′-triiodothyronine (T 3 ; Eales & Brown 1993 ). This

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Antonella Amato, Sara Baldassano, and Flavia Mulè

also produced in a discrete population of neurons in the brainstem, which projects mainly to the hypothalamus, brain area that plays a key role in control of food intake ( Vrang et al. 2007 ). Prohormone convertase 1/3 (PC1/3) processes proglucagon in