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L Lundholm, G Bryzgalova, H Gao, N Portwood, S Fält, K D Berndt, A Dicker, D Galuska, J R Zierath, J-Å Gustafsson, S Efendic, K Dahlman-Wright, and A Khan

, member 1 Suppressor of cytokine signaling 2 Syndecan 4 Decreased by PPT and E 2 Butyrylcholinesterase Esterase 22 Fatty acid desaturase 2 Glucose-6-phosphatase, catalytic Glutamate-cysteine ligase, catalytic subunit Glutathione S-transferase, α 2 (Yc2

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V E MacRae, C Farquharson, and S F Ahmed

, cytokines may induce a state of IGF-I resistance by reducing IGF-I signal transduction in chondrocytes by inhibiting insulin receptor substrate-1 phosphorylation ( Broussard et al. 2004 ) by the up-regulation of the suppressor of cytokine-signalling

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Richard R Almon, Debra C DuBois, Jin Y Jin, and William J Jusko

. Martinez-Riquelme AE & Allison SP 2003 Insulin revisited. Clinical Nutrition 22 7 –15. Mooney RA , Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y & Furlanetto RW 2001 Suppressors of cytokine signaling-1 and -6

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R P Rhoads, J W Kim, M E Van Amburgh, R A Ehrhardt, S J Frank, and Y R Boisclair

the 18S signal. Real-time SYBR green PCR assays were used to measure transcript abundance of GHR1B, GHR1C, suppressor of cytokine signaling-3 (SOCS3), and p85 regulatory subunit of phosphatidylinositol 3-kinase (p85-PI3KR1) and 18S (Table 1

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Marion Walser, Maria Teresa Samà, Ruth Wickelgren, Maria Åberg, Mohammad Bohlooly-Y, Bob Olsson, Jan Törnell, Jörgen Isgaard, and N David Åberg

numbers ( Ransome et al . 2004 ), while increasing GH signalling via disrupting the suppressor of cytokine signalling 2 (SOCS2) decreased neuron numbers and presumably increased astrocyte numbers ( Turnley et al . 2002 ). Neither from these studies nor

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J G Miquet, A I Sotelo, A Bartke, and D Turyn

signaling regulation. The members of the suppressors of cytokine signaling (SOCS) family of proteins SOCS-1 and SOCS-3 inhibit JAK2 activity ( Greenhalgh & Hilton 2001 ), while the SH2 domain-containing protein-tyrosine phosphatase-2 (SHP-2) binds to

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Sebastian Weise, Susan Kralisch, Grit Sommer, Ulrike Lossner, Matthias Bluher, Michael Stumvoll, and Mathias Fasshauer

membrane through downregulation of insulin receptor substrate-1 ( Jager et al . 2007 ). Furthermore, long-term IL-1α stimulation of 3T3-L1 adipocytes induced expression of suppressor of cytokine signaling-1 and -3 ( He et al . 2006 ), which are well

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Gayathri Swaminathan, Bentley Varghese, Chellappagounder Thangavel, Christopher J Carbone, Alexander Plotnikov, K G Suresh Kumar, Elizabeth M Jablonski, Charles V Clevenger, Vincent Goffin, Luqin Deng, Stuart J Frank, and Serge Y Fuchs

. Irandoust MI Aarts LH Roovers O Gits J Erkeland SJ Touw IP 2007 Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor . EMBO Journal 26 1782 – 1793 . Kohlhuber F Rogers NC Watling

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Fausto Bogazzi, Dania Russo, Francesco Raggi, Mohammad Bohlooly-Y, Jan Tornell, Chiara Sardella, Martina Lombardi, Claudio Urbani, Luca Manetti, Sandra Brogioni, and Enio Martino

doi:10.1210/en.2008-0346 . Bogazzi F Ultimieri F Raggi F Russo D Costa A Marciano E Bartalena L Martino E 2009a Changes in the expression of suppressor of cytokine signaling (SOCS) 2 in the colonic mucosa of acromegalic patients are

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Susan Kralisch, Johannes Klein, Ulrike Lossner, Matthias Bluher, Ralf Paschke, Michael Stumvoll, and Mathias Fasshauer

suggest that downregulation of visfatin in adipocytes may contribute to impaired glucose tolerance caused by increased GH levels. However, it has to be pointed out that stimulation of suppressor of cytokine signaling (SOCS)-1 ( Fasshauer et al. 2004 b