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Jennifer D Spencer, Bhaven Chavan, Lee K Marles, Sobia Kauser, Hartmut Rokos, and Karin U Schallreuter

processing machinery, including prohormone convertases 1/2 (PC1, PC2) and 7B2, have been demonstrated inside the melanosome of epidermal and hair follicle melanocytes, it was expected that β-MSH is also present in this organelle ( Peters et al. 2000

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Alessandro Pocai

proteolytically cleaved in a tissue-specific manner by prohormone convertases 1 and 2. The numbers in the figure indicate amino acid positions in the 160-amino acid proglucagon sequence. In the pancreas, processing yields the glucagon sequence, whereas the region

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Michal A Zmijewski, Rajesh K Sharma, and Andrzej T Slominski

.g. 100% of their sequence homology with POMC was shown in previous experiments ( Pisarchik & Slominski 2004 , Slominski et al. 2005 ). Since processing of POMC precursor requires the presence of both prohormone convertases 1 and 2 (PC1 and PC2), we

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H Kulaksiz, F Theilig, S Bachmann, S G Gehrke, D Rost, A Janetzko, Y Cetin, and W Stremmel

serial sections were used. Slides were evaluated with a digital camera (Spot; Diagnostic Instruments), processed with MetaVue software (Universal Imaging; Visitron, Puchheim, Germany) and viewed with a Leica light microscope equipped with an high pressure

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Stephen G Hillier

. 2016 ). All arthropod species moult ( Chang & Mykles 2011 ). It is a defining feature of animals with a rigid exoskeleton, which is split and shed to accommodate serial phases of growth and development ( Nijhout & Callier 2015 ) ( Box 2 ). The process

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K Hamano, M Awaji, and H Usuki

, Rubakhin SS, Sweedler JV, Horn CC, Kupfermann I, Alexeeva VY, Ellis TA, Dembrow NC, Weiss KR & Vilim FS 1999 Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica . Journal of Neuroscience 15 7732 –7741

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K Eerola, P Rinne, A M Penttinen, L Vähätalo, M Savontaus, and E Savontaus

of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC . FEBS Letters 310 235 – 239 . ( doi:10.1016/0014-5793(92)81339-N ) Semjonous et al. 2009 Semjonous

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George Schlossmacher, Adam Stevens, and Anne White

survival pathways and this can result in reversible growth arrest or cell death in certain cell types. Endogenous Gcs are involved in a variety of biological processes. In man, Gcs have important effects on metabolism, the immune response, development, the

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I Sadaf Farooqi and Stephen O'Rahilly

'Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene [see comments] . Nature Genetics 16 303 – 306 . ( doi:10.1038/ng0797-303 ) Krude H Biebermann H Luck W Horn R

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Celia Siu, Sam Wiseman, Sitanshu Gakkhar, Alireza Heravi-Moussavi, Misha Bilenky, Annaick Carles, Thomas Sierocinski, Angela Tam, Eric Zhao, Katayoon Kasaian, Richard A Moore, Andrew J Mungall, Blair Walker, Thomas Thomson, Marco A Marra, Martin Hirst, and Steven J M Jones

decipher the human epigenomes of various cell types in order to understand how epigenetic processes contribute to human biology and disease ( Stunnenberg et al. 2016 ). The goals of this work are to provide a resource of human thyroid epigenomic data