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Kook Hwan Kim and Myung-Shik Lee

). Furthermore, hepatic FGF21 actions such as alleviation of steatosis and suppression of hepatic glucose production were less pronounced in these mice, suggesting indirect FGF21 action on the liver. These findings suggest that both adipose tissue and the brain

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Cristina Mora, Cristina Pintado, Blanca Rubio, Lorena Mazuecos, Virginia López, Alejandro Fernández, Aurora Salamanca, Brenda Bárcena, Teresa Fernández-Agulló, Carmen Arribas, Nilda Gallardo, and Antonio Andrés

perfused working rat hearts, earlier work revealed that acute peripheral leptin administration decreased heart TAG content ( Atkinson et al. 2002 ). A similar decrease was also observed in a transgenic mice model of myocardial steatosis upon chronic

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Min Liu, Shuo Xie, Weiwei Liu, Jingjin Li, Chao Li, Wei Huang, Hexin Li, Jinghai Song, and Hong Zhang

SEMA3F, thereby activating AMPK ( Wu et al . 2016 ). The combination of honokiol and magnolol (HM) blunts hepatic steatosis and SREBP-1c-mediated hepatic lipogenesis, which may be triggered by AMPK phosphorylation and ACC ( Lee et al . 2015 ). AZF

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Wonsuk Choi, Joon Ho Moon, and Hail Kim

). Under HFD-fed conditions, inhibiting gut-derived 5-HT synthesis ameliorates hepatic steatosis by reducing hepatic HTR2A signaling ( Choi et al. 2018 ). Both gut-specific Tph1 and hepatocyte-specific Htr2a knock-out mice are resistant to HFD

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Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, and Margit Mahlapuu

steatosis) in the development of type 2 diabetes, atherosclerosis, acute pancreatitis and pancreatic cancer ( Catanzaro et al. 2016 ). In spite of this high medical relevance and an estimated prevalence between 16 and 35% ( Wang et al. 2014 , Lesmana

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Mary C Sugden, Paul W Caton, and Mark J Holness

5 ( Lerin et al . 2006 ). Studies of the role of PGC-1α on energy metabolism have mainly utilized gain-of-function or complete-loss-of-function models. Total ablation of hepatic PGC-1α elicits fasting steatosis; however, insulin sensitivity and

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Sandra Ghelardoni, Grazia Chiellini, Sabina Frascarelli, Alessandro Saba, and Riccardo Zucchi

 μg/ml streptomycin, and 4 mM glutamine, supplemented with 1 g/l glucose and 1 mM sodium pyruvate. To induce steatosis, HepG2 were exposed to exogenous lipids as described ( Di Nunzio et al . 2011 , Yao et al . 2011 ). Cells were incubated with 1 μM

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Makoto Ito, Akira Gomori, Jun Suzuki, Shigeharu Tsujioka, Minoru Sasaki, Masao Matsuda, Maria A Bednarek, Masahiko Ito, Akane Ishihara, Hisashi Iwaasa, Douglas J MacNeil, and Akio Kanatani

Introduction With the growing prevalence of metabolic disorders, nonalcoholic fatty liver diseases (NAFLD), which range from simple steatosis to end stage liver disease, have become a common cause of chronic liver diseases ( Marchesini et al . 2003

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Mark A Exley, Laura Hand, Donal O'Shea, and Lydia Lynch

now a major public health issue, with the principal cause of morbidity due to metabolic dysfunction (insulin resistance, type 2 diabetes, dyslipidemia, hepatic steatosis, and cardiovascular disease). Progression of clinical pathology has been strongly

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Eva B Nygaard, Cathrine Ørskov, Thomas Almdal, Henrik Vestergaard, and Birgitte Andersen

three-fold increase in FFA ( Rasmussen et al . 2003 ) in obese subjects during the 60 h of fasting and indicate that other factors such as hepatic steatosis may regulate plasma FGF21 ( Li et al . 2010 , Yan et al . 2011 ). In agreement with this