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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn, and Joseph Proietto

. Chong MM , Thomas HE & Kay TW 2002 Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. Journal of Biological Chemistry 277 27945 –27952. Coleman DL & Hummel

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Camila Calvino, Luana L Souza, Ricardo H Costa-e-Sousa, Norma A S Almeida, Isis H Trevenzoli, and Carmen C Pazos-Moura

). pSTAT3 induces the transcription of several genes, including suppressor of cytokine signalling 3 (SOCS3), which inhibits JAK2–STAT3 signalling, leading to central leptin resistance ( Bjørbaek et al . 1999 , Flier 2004 , Howard et al . 2004 , Donato

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Sharon H Chou and Christos Mantzoros

-Haschimi et al . 2000 ), impaired leptin signaling by suppressor of cytokine signaling 3 (SOCS3; Bjorbaek et al . 1998 , Dunn et al . 2005 ), impaired leptin receptor trafficking ( Bjornholm et al . 2007 , Morrison et al . 2007 ), saturation of leptin

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M K Piya, P G McTernan, and S Kumar

in adipose tissue and hepatic tissue, IL6 is shown to be a pro-inflammatory adipokine. It increases insulin resistance by up-regulating suppressor of cytokine signalling 3 (SOCS3), which, in turn, impairs insulin-induced insulin receptor and IRS1

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Mark O Huising, Corine P Kruiswijk, and Gert Flik

members of the suppressor of cytokine signalling (SOCS) family. Currently the SOCS family consists of eight members (SOCS1–7 and cytokine-inducible SH2-containing domain (CIS)); the role of SOCS4–7 in cytokine signalling has received limited attention. The

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Lenka Maletínská, Andrea Popelová, Blanka Železná, Michal Bencze, and Jaroslav Kuneš

, a decrease in Akt activation through an increase in suppressor of cytokine signaling (SOCS3) was linked to an inefficient leptin signaling ( King et al . 2018 ). Figure 2 Scheme of potential neuroprotective effects of anorexigenic peptides

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Marina C Muñoz, Jorge F Giani, Marcos A Mayer, Jorge E Toblli, Daniel Turyn, and Fernando P Dominici

-kappaB . Nature Medicine 11 183 – 190 . Calegari VC Alves M Picardi PK Inoue RY Franchini KG Saad MJ Velloso LA 2005 Suppressor of cytokine signaling-3 provides a novel interface in the cross-talk between angiotensin II and insulin signaling

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Rajat Kumar Das, Sarmistha Banerjee, and Bernard H Shapiro

contradiction with the accompanying ∼90% decline in CYP2C11 mRNA and protein. However, the episodic GH/JAK2/STAT5B signal transduction pathway is negatively regulated by tyrosine phosphatases ( Frank 2001 , Waxman & O'Connor 2006 ) and suppressors of cytokine

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C García-Luna, P Soberanes-Chávez, and P de Gortari

the leptin receptor ( Obrb ) and suppressor of cytokine signaling 3 (SOCS3)) and PVN mRNAs ( Trh , Crf , obrb and Socs3 ). PVN (−0.84 to −2.28 mm from bregma) and ARC (−2.28 to −3.48 mm from bregma) ( Paxinos & Watson 2005 ) were punch

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Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra, and Urszula T Iwaniec

the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in