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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn, and Joseph Proietto
Teresa Priego, Miriam Granado, Estibaliz Castillero, Ana Isabel Martín, M Ángeles Villanúa, and Asunción López-Calderón
( Peinnequin et al. 2004 ), suppressor of cytokine signaling-3 (SOCS-3) forward: CCTCCAG-CATCTTTGTCGGAAGAC; SOCS-3 reverse: TACTGG-TCCAGGAACTCCCGAATG; hypoxanthine–guanine phosphorybosyl transferase (Hprt) forward: CTCATG-GACTGATTATGGACAGGAC; Hprt reverse
M K Piya, P G McTernan, and S Kumar
in adipose tissue and hepatic tissue, IL6 is shown to be a pro-inflammatory adipokine. It increases insulin resistance by up-regulating suppressor of cytokine signalling 3 (SOCS3), which, in turn, impairs insulin-induced insulin receptor and IRS1
Sharon H Chou and Christos Mantzoros
-Haschimi et al . 2000 ), impaired leptin signaling by suppressor of cytokine signaling 3 (SOCS3; Bjorbaek et al . 1998 , Dunn et al . 2005 ), impaired leptin receptor trafficking ( Bjornholm et al . 2007 , Morrison et al . 2007 ), saturation of leptin
Mark O Huising, Corine P Kruiswijk, and Gert Flik
members of the suppressor of cytokine signalling (SOCS) family. Currently the SOCS family consists of eight members (SOCS1–7 and cytokine-inducible SH2-containing domain (CIS)); the role of SOCS4–7 in cytokine signalling has received limited attention. The
Lenka Maletínská, Andrea Popelová, Blanka Železná, Michal Bencze, and Jaroslav Kuneš
, a decrease in Akt activation through an increase in suppressor of cytokine signaling (SOCS3) was linked to an inefficient leptin signaling ( King et al . 2018 ). Figure 2 Scheme of potential neuroprotective effects of anorexigenic peptides
Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra, and Urszula T Iwaniec
the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in
M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum, and V White
.placenta.2009.01.004 ) Vila L Roglans N Alegret M Sanchez RM Vazquez-Carrera M Laguna JC 2008 Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the
Misuzu Yamashita, Fumio Otsuka, Tomoyuki Mukai, Hiroyuki Otani, Kenichi Inagaki, Tomoko Miyoshi, Junko Goto, Masahiro Yamamura, and Hirofumi Makino
osteogenetic process. There has been recent evidence indicating that the effects of TNF-α are primarily associated with activation of MAPK signaling, which subsequently increases the activation of stress-related proteins such as NF-κB and suppressor of cytokine
Rajat K Das, Sarmistha Banerjee, and Bernard H Shapiro
anti-suppressors of cytokine signaling (CIS and SOCS2). Nuclear fractions were immune precipitated with signal transducers and activators of transcription 5b (STAT5b) antibodies as described previously ( Thangavel & Shapiro 2007 , Banerjee et al
