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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn, and Joseph Proietto

. Chong MM , Thomas HE & Kay TW 2002 Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. Journal of Biological Chemistry 277 27945 –27952. Coleman DL & Hummel

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Bettina A Ikenasio-Thorpe, Bernhard H Breier, Mark H Vickers, and Mhoyra Fraser

reduced signal transducer and activator of transcription-3 (STAT-3) activation, and involving increased expression of suppressor of cytokine signalling-3 (SOCS-3), an inhibitor of leptin signalling ( Munzberg et al. 2004 ). Our observation of increased

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Sharon H Chou and Christos Mantzoros

-Haschimi et al . 2000 ), impaired leptin signaling by suppressor of cytokine signaling 3 (SOCS3; Bjorbaek et al . 1998 , Dunn et al . 2005 ), impaired leptin receptor trafficking ( Bjornholm et al . 2007 , Morrison et al . 2007 ), saturation of leptin

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M K Piya, P G McTernan, and S Kumar

in adipose tissue and hepatic tissue, IL6 is shown to be a pro-inflammatory adipokine. It increases insulin resistance by up-regulating suppressor of cytokine signalling 3 (SOCS3), which, in turn, impairs insulin-induced insulin receptor and IRS1

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Mark O Huising, Corine P Kruiswijk, and Gert Flik

members of the suppressor of cytokine signalling (SOCS) family. Currently the SOCS family consists of eight members (SOCS1–7 and cytokine-inducible SH2-containing domain (CIS)); the role of SOCS4–7 in cytokine signalling has received limited attention. The

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Lenka Maletínská, Andrea Popelová, Blanka Železná, Michal Bencze, and Jaroslav Kuneš

, a decrease in Akt activation through an increase in suppressor of cytokine signaling (SOCS3) was linked to an inefficient leptin signaling ( King et al . 2018 ). Figure 2 Scheme of potential neuroprotective effects of anorexigenic peptides

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Mohan Singh, Parvesh Chaudhry, and Eric Asselin

C Boeuf H 2000 Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival . FASEB Journal 14 1577 – 1584 doi:10.1096/fj.14.11.1577 . Ernst M Inglese M Waring P

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Marina C Muñoz, Jorge F Giani, Marcos A Mayer, Jorge E Toblli, Daniel Turyn, and Fernando P Dominici

-kappaB . Nature Medicine 11 183 – 190 . Calegari VC Alves M Picardi PK Inoue RY Franchini KG Saad MJ Velloso LA 2005 Suppressor of cytokine signaling-3 provides a novel interface in the cross-talk between angiotensin II and insulin signaling

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Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra, and Urszula T Iwaniec

the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in

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Lisa Rice, Charlotte E Waters, Jennifer Eccles, Helen Garside, Paula Sommer, Paul Kay, Fiona H Blackhall, Leo Zeef, Brian Telfer, Ian Stratford, Rob Clarke, Dave Singh, Adam Stevens, Anne White, and David W Ray

  EMR1 2015 207111_at −2.0 0.185 EGF-like module containing, mucin-like, hormone receptor-like 1   SOCS3 9021 227697_at −1.9 0.198 Suppressor of cytokine signalling 3   LRP12 29 967 220254_at −1.9 0.143 Low density lipoprotein-related protein 12   RGS17