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Natalia Ogonowski, Giselle Piro, Déborah Pessah, Noelia Arreche, Bernardita Puchulu, Ana M Balaszczuk, and Andrea L Fellet

hypothyroidism ( Wang et al. 2010 , Sarati et al. 2012 ) and concentric left ventricle hypertrophy associated with thyrotoxicosis ( Abergel et al. 1995 ). The mechanisms of the animal model of thyroid disturbances-induced cardiac hypertrophy are

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Isabel Rodríguez-Gómez, Inmaculada Banegas, Rosemary Wangensteen, Andrés Quesada, Rosario Jiménez, Mercedes Gómez-Morales, Francisco O'Valle, Juan Duarte, and Félix Vargas

Introduction Thyroid hormone (TH) can induce cardiac hypertrophy and angiogenesis in several animal models ( Chilian et al . 1985 , Weiss & Grover 1987 , Breisch et al . 1989 , Tomanek et al . 1998 ), and TH and the TH analogue 3

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Danielle Brown, Amiya P Sinha Hikim, Ekaterina L Kovacheva, and Indrani Sinha-Hikim

Q Mollkentin JD 2003 Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models . Journal of Molecular and Cellular Cardiology 35 1385 – 1394 . Lin A Dibling B 2002

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Jarrad M Scarlett, Darren D Bowe, Xinxia Zhu, Ayesha K Batra, Wilmon F Grant, and Daniel L Marks

WT-Sham 0.16±0.01 g, P <0.001; Table 1 ). The HW-to-BW ratio (HW:BW), a well-established index of cardiac hypertrophy, was significantly greater for WT-MI mice compared to WT-Sham mice (WT-MI 13.7±0.54 g versus WT-Sham 6.39±0.17 g, P <0.001; Table

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Apiwan Arinno, Nattayaporn Apaijai, Puntarik Kaewthep, Wasana Pratchayasakul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C Chattipakorn, and Nipon Chattipakorn

studies showed that 12 weeks of HFD consumption led to obesity, insulin resistance and dyslipidemia in rats ( Pratchayasakul et al. 2011 , Apaijai et al. 2012 ) and is associated with an increase in blood pressure, cardiac sympathovagal imbalance and

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Takuya Yoshino, Tomohisa Nagoshi, Ryuko Anzawa, Yusuke Kashiwagi, Keiichi Ito, Daisuke Katoh, Masami Fujisaki, Yosuke Kayama, Taro Date, Kenichi Hongo, and Michihiro Yoshimura

, Sanada et al . 2001 , Cai & Semenza 2004 , Hausenloy & Yellon 2006 , Schmidt et al . 2010 , Turrell et al . 2011 ). Aldosterone, one of the major neurohumoral factors acting under critical cardiac conditions (such as acute-phase ischemic heart

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Natasha N Chattergoon

; hypertrophy). Cardiomyocytes from TX fetuses were also wider to maintain wall stress and cardiac function. Bars that do not share letters are significantly different ( P  < 0.05); n  = 8. Data are mean ±  s.e.m. Reproduced, with permission, from Chattergoon

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John M C Connell and Eleanor Davies

balance in epithelial tissue, aldosterone in the cardiovascular system promotes cardiac hypertrophy, fibrosis and abnormal vascular endothelial function. In the CNS, it appears to regulate blood pressure, salt appetite and sympathetic tone

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Timothy J Cole and Morag J Young

showed that cardiomyocyte MR null also contributed to electromechanical responses to cardiac hypertrophy and damage at least in part due to changes in NHE-1 levels and phosphorylation of Calcium/calmodulin kinase 2 (CamKs) ( Bienvenu et al . 2015

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Qiong You, Zijun Wu, Bin Wu, Chang Liu, Ruina Huang, Li Yang, Runmin Guo, Keng Wu, and Jingfu Chen

dysfunction, hypertrophy and cardiac fibrosis ( van Heerebeek et al . 2008 ) in DCM. Thus, NF-κB plays a key role in the development of DCM. However, the role of NF-κB in hyperglycemia-induced hypertrophy and cardiac fibrosis in the cardioprotective action of