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Takuro Okamura, Yoshitaka Hashimoto, Takafumi Osaka, Takafumi Senmaru, Takuya Fukuda, Masahide Hamaguchi, and Michiaki Fukui

with COPD . Age and Ageing 548 – 553 . ( https://doi.org/10.1093/ageing/aft196 ) Axell AM MacLean HE Plant DR Harcourt LJ Davis JA Jimenez M Handelsman DJ Lynch GS Zajac JD 2006 Continuous testosterone administration prevents

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Prashant Regmi, Rajesh Chaudhary, Amanda J Page, Amy T Hutchison, Andrew D Vincent, Bo Liu, and Leonie Heilbronn

a pivotal role in energy metabolism, sirtuin (SIRT) function, and biological ageing ( Poljsak 2018 ). The majority of cellular NAD was thought to come from the nicotinamide phosphoribosyltransferase (NAMPT) mediated salvage pathway, whose amplitude

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Marleen B Dommerholt, Derek A Dionne, Daria F Hutchinson, Janine K Kruit, and James D Johnson

.1016/j.exger.2014.08.010 25152388 Kapahi P Kaeberlein M Hansen M 2017 Dietary restriction and lifespan: lessons from invertebrate models . Ageing Research Reviews 39 3 – 14 . ( https://doi.org/10.1016/j.arr.2016.12.005 ) 28007498 10

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Nava Chapnik, Gili Solomon, Yoni Genzer, Ruth Miskin, Arieh Gertler, and Oren Froy

Yahav S Dubnov G Kohen R 2005 αMUPA mice: a transgenic model for longevity induced by caloric restriction . Mechanisms of Ageing and Development 126 255 – 261 . ( doi:10.1016/j.mad.2004.08.018 ) Miskin R Masos T Shoham Z Williams

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M Alves, D Andrade Cunha, V Cristine Calegari, M J A Saad, A Carlos Boschero, L Augusto Velloso, and E Melani Rocha

lacrimal gland acini with ageing. Experimental Eye Research 68 265 –276. Draper CE , Singh J & Adeghate E 2003 Effects of age on morphology, protein synthesis and secretagogue-evoked secretory responses in the rat lacrimal

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Dawn E W Livingstone, Emma M Di Rollo, Tracy C-S Mak, Karen Sooy, Brian R Walker, and Ruth Andrew

signalling or indeed both. Insulin resistance is a feature of both excess glucocorticoid production, for example in Cushing’s Syndrome, and also low circulating testosterone with ageing ( Cheung et al. 2015 ). In vivo dissection of the distinct

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Sophie A Clarke and Waljit S Dhillo

triggers to assess how clinically useful it will be. However, early evidence appears promising. Kisspeptin and ageing Kisspeptin and the menopause The utility of kisspeptin extends beyond that of the reproductive age. Post-menopausal women

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Pegah JafariNasabian, Julia E Inglis, Wendimere Reilly, Owen J Kelly, and Jasminka Z Ilich

Y Schneider SM 2010 Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing 39 412 – 423 . ( doi:10.1093/ageing/afq034 ) Dawson-Hughes B

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Parveen Abidi, Haiyan Zhang, Syed M Zaidi, Wen-Jun Shen, Susan Leers-Sucheta, Yuan Cortez, Jiahuai Han, and Salman Azhar

AR 1995 PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo . Journal of Biological Chemistry 270 27489 – 27494 . Arlt W 2004 Dehydroepiandrosterone and ageing . Best Practice and

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Hassina Ould Hamouda, Bernadette Delplanque, Yacir Benomar, Delphine Crépin, Laure Riffault, Pascale LeRuyet, Cécile Bonhomme, and Mohammed Taouis

Carter C Yu BP Leewenburgh C 2009 Molecular inflammation: underpinnings of aging and age-related diseases . Ageing Research Reviews 8 19 – 30 . ( doi:10.1016/j.arr.2008.07.002 ) Dangin M Guillet C Garcia-Rodenas C Gachon P Bouteloup