been reported in ruminants. In scheduled meal-fed sheep, therefore, we examined the effects of ghrelin administration on insulin secretory response to glucose load and on insulin sensitivity in the postprandial period, when insulin secretory response is
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H Takahashi, Y Kurose, S Kobayashi, T Sugino, M Kojima, K Kangawa, Y Hasegawa, and Y Terashima
May Faraj, Genevieve Beauregard, Emmanuelle Loizon, Marthe Moldes, Karine Clément, Youssef Tahiri, Katherine Cianflone, Hubert Vidal, and Rémi Rabasa-Lhoret
data. S.c. WAT adiponutrin expression was not increased in obese subjects and was associated with insulin sensitivity in one study ( Liu et al. 2004 ) but not in the other (where insulin sensitivity was associated with adiponutrin expression in
Sergio Di Meo, Susanna Iossa, and Paola Venditti
treatment have been intensified. In addition to dietary regimes aimed at weight loss, two major non-pharmacological approaches to improve insulin sensitivity have included antioxidant supplementation and exercise training. In recent years, antioxidants
Sung-Soo Park, Yeon-Joo Lee, Sooyeon Song, Boyong Kim, Hyuno Kang, Sejong Oh, and Eungseok Kim
activation, respectively, resulting in protection against HFD-induced obesity and fat accumulation in the liver, with improvement in insulin sensitivity. Furthermore, AMPK was shown to play a key role in LNS1-mediated regulation of PPARα and SREBP-1c
Muraly Puttabyatappa, Robert M Sargis, and Vasantha Padmanabhan
offspring exhibit postnatal signs of reduced insulin sensitivity ( Tamhane et al . 2018 ). Evidence indicates that during pregnancy women with PCOS have higher androgen levels with associated disruptions in placental steroidogenesis ( Sir-Petermann et al
Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki
composition, glucose tolerance, and insulin sensitivity under carbohydrate-based normal diet feeding condition using GIP-knockout mice. Materials and methods Animals GIP-knockout mice were generated previously ( Nasteska et al . 2014 ). GIP
Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr, and Brant R Burkhardt
by GTT performed on 6-month-old mice, but both groups showed elevated glucose levels during the course of GTT as compared with the younger cohort ( Fig. 3 B). To evaluate peripheral insulin sensitivity, ITTs were performed. ITT results demonstrated
Ljupka Gligorovska, Biljana Bursać, Sanja Kovačević, Nataša Veličković, Gordana Matić, and Ana Djordjevic
reporting that Mif - knockout mice display improved insulin sensitivity and glucose tolerance ( Verschuren et al. 2009 , Kleemann & Bucala 2010 ). Although MIF synthesis and secretion are upregulated by the glucocorticoid hormones (GCs), MIF acts as
M Skrzypski, M Billert, K W Nowak, and M Z Strowski
). Furthermore, orexin is required to maintain motor activity ( Hara et al . 2001 ) as well hypothalamic insulin signaling, which results in improvement of peripheral insulin sensitivity ( Tsuneki et al . 2008 ). Maintenance of body weight and energy
Marco Hatem-Vaquero, Mercedes Griera, Andrea García-Jerez, Alicia Luengo, Julia Álvarez, José A Rubio, Laura Calleros, Diego Rodríguez-Puyol, Manuel Rodríguez-Puyol, and Sergio De Frutos
homeostasis model assessment of insulin resistance (HOMA-IR, fasting glycemia in mg/dL multiplied by fasting insulinemia in µU/mL, divided to 405) and the quantitative insulin sensitivity check index (QUICKI, 1 divided to log fasting insulinemia in µU/mL plus
