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Christophe Breton

activates the expression of suppressors of cytokine signalling 3 (SOCS3) that in turn inhibits leptin-induced tyrosine phosphorylation of JAK2 and STAT3 activation (indicated in red). The direct cross talk between insulin and leptin signalling at the level

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Christopher M Mulligan and Jacob E Friedman

suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance . Diabetes Care 32 2281 – 2287 . ( doi:10.2337/dbib9-0979 ) Ghanim H Sia CL Upadhyay M Korzeniewski K

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C García-Luna, P Soberanes-Chávez, and P de Gortari

the leptin receptor ( Obrb ) and suppressor of cytokine signaling 3 (SOCS3)) and PVN mRNAs ( Trh , Crf , obrb and Socs3 ). PVN (−0.84 to −2.28 mm from bregma) and ARC (−2.28 to −3.48 mm from bregma) ( Paxinos & Watson 2005 ) were punch

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Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, and Lucila L K Elias

Stereotaxic Coordinates . San Diego, CA, USA : Academic Press . Peiser C McGregor GP Lang RE 2000 Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats . Life Sciences 67 . ( https://doi.org/10

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Lisa Rice, Charlotte E Waters, Jennifer Eccles, Helen Garside, Paula Sommer, Paul Kay, Fiona H Blackhall, Leo Zeef, Brian Telfer, Ian Stratford, Rob Clarke, Dave Singh, Adam Stevens, Anne White, and David W Ray

  EMR1 2015 207111_at −2.0 0.185 EGF-like module containing, mucin-like, hormone receptor-like 1   SOCS3 9021 227697_at −1.9 0.198 Suppressor of cytokine signalling 3   LRP12 29 967 220254_at −1.9 0.143 Low density lipoprotein-related protein 12   RGS17

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Rajat K Das, Sarmistha Banerjee, and Bernard H Shapiro

anti-suppressors of cytokine signaling (CIS and SOCS2). Nuclear fractions were immune precipitated with signal transducers and activators of transcription 5b (STAT5b) antibodies as described previously ( Thangavel & Shapiro 2007 , Banerjee et al

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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum, and V White

.placenta.2009.01.004 ) Vila L Roglans N Alegret M Sanchez RM Vazquez-Carrera M Laguna JC 2008 Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the

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Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra, and Urszula T Iwaniec

the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in

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Susan Kralisch, Anke Tönjes, Kerstin Krause, Judit Richter, Ulrike Lossner, Peter Kovacs, Thomas Ebert, Matthias Blüher, Michael Stumvoll, and Mathias Fasshauer

. FGF21-mediated suppression of STAT5 is accompanied by decreases in the expression of its target genes including IGF1 ( Inagaki et al . 2008 ). Furthermore, FGF21 induces hepatic expression of IGF1 binding protein 1 and suppressor of cytokine signaling

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Simon J Dunmore and James E P Brown

gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells . Diabetes 54 3410 – 3417 . ( doi:10.2337/diabetes.54.12.3410 ) Leahy JL Hirsch IB Peterson KA Schneider D 2010 Targeting β-cell function