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Lorena González, Johanna G Miquet, Pablo E Irene, M Eugenia Díaz, Soledad P Rossi, Ana I Sotelo, Mónica B Frungieri, Cristal M Hill, Andrzej Bartke, and Daniel Turyn

.mrrev.2009.01.001 ) Wu WY Kim H Zhang CL Meng XL Wu ZS 2014 Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma . Journal of Investigative Surgery 27 197 – 204 . ( doi:10

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Lorena González, Ma. Eugenia Díaz, Johanna G Miquet, Ana I Sotelo, Diego Fernández, Fernando P Dominici, Andrzej Bartke, and Daniel Turyn

context, breast cancer cells overexpressing the estrogen receptor ( Boerner et al . 2005 ). The activation of the STATs is highly regulated but incompletely understood. GRB2 and suppressors of cytokine signaling (SOCS) can inhibit STAT-mediated EGFR

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Rajat K Das, Sarmistha Banerjee, and Bernard H Shapiro

anti-suppressors of cytokine signaling (CIS and SOCS2). Nuclear fractions were immune precipitated with signal transducers and activators of transcription 5b (STAT5b) antibodies as described previously ( Thangavel & Shapiro 2007 , Banerjee et al

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Rajat Kumar Das, Sarmistha Banerjee, and Bernard H Shapiro

contradiction with the accompanying ∼90% decline in CYP2C11 mRNA and protein. However, the episodic GH/JAK2/STAT5B signal transduction pathway is negatively regulated by tyrosine phosphatases ( Frank 2001 , Waxman & O'Connor 2006 ) and suppressors of cytokine

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Sara Yosefi, Gideon Hen, Charles I Rosenblum, David J Cerasale, Michaël Beaulieu, Francois Criscuolo, and Miriam Friedman-Einat

Klingenspor M 2004 Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus , is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression . Endocrinology 145 1185 – 1193 doi:10.1210/en

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Martha Lappas

expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes . Gynecological Endocrinology 28 841 – 844 . ( doi:10.3109/09513590.2012.683055 ) Kvarnhammar et al. 2013 Kvarnhammar AM Tengroth

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Mohan Singh, Parvesh Chaudhry, and Eric Asselin

C Boeuf H 2000 Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival . FASEB Journal 14 1577 – 1584 doi:10.1096/fj.14.11.1577 . Ernst M Inglese M Waring P

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Christophe Breton

activates the expression of suppressors of cytokine signalling 3 (SOCS3) that in turn inhibits leptin-induced tyrosine phosphorylation of JAK2 and STAT3 activation (indicated in red). The direct cross talk between insulin and leptin signalling at the level

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Simon J Dunmore and James E P Brown

gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells . Diabetes 54 3410 – 3417 . ( doi:10.2337/diabetes.54.12.3410 ) Leahy JL Hirsch IB Peterson KA Schneider D 2010 Targeting β-cell function

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E Oliveira, C R Pinheiro, A P Santos-Silva, I H Trevenzoli, Y Abreu-Villaça, J F Nogueira Neto, A M Reis, M C F Passos, E G Moura, and P C Lisboa

-desensitization between leptin and prolactin signaling pathways despite the induction of suppressor of cytokine signaling 3 and PTP-1B . Journal of Endocrinology 195 341 – 350 . Sala F Nistri A Criado M 2008 Nicotinic acetylcholine receptors of adrenal