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Vivian Cristine Calegari, Claudio Cesar Zoppi, Luiz Fernando Rezende, Leonardo Reis Silveira, Everardo Magalhães Carneiro, and Antonio Carlos Boschero

skeletal muscle insulin action, ongoing evidence points toward its systemic effect in other tissues, which, in turn, are also involved in blood glucose homeostasis. In this sense, exercise increases liver insulin sensitivity ( Hoene et al . 2009 ) reducing

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Jay W Porter, Joe L Rowles III, Justin A Fletcher, Terese M Zidon, Nathan C Winn, Leighton T McCabe, Young-Min Park, James W Perfield II, John P Thyfault, R Scott Rector, Jaume Padilla, and Victoria J Vieira-Potter

.05). Exercise improves adipose tissue insulin sensitivity in FGF21KO mice Based on HOMA-IR values, FGF21KO mice were significantly more insulin-resistant than WT controls ( Fig. 1A ) and EX had a tendency ( P  = 0.112) to improve HOMA-IR in both genotypes

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Mercedes Lombarte, Brenda L Fina, Maela Lupo, Marília A Buzalaf, and Alfredo Rigalli

tissue by increasing the number of GLUT4 transporters ( Jørgensen et al . 2007 ). As a consequence, physical activity increases insulin sensitivity in the muscle ( Wojtaszewski & Richter 2006 ). Therefore, the aim of this study was to evaluate the effect

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L Lundholm, G Bryzgalova, H Gao, N Portwood, S Fält, K D Berndt, A Dicker, D Galuska, J R Zierath, J-Å Gustafsson, S Efendic, K Dahlman-Wright, and A Khan

risk of developing type 2 diabetes ( Louet et al . 2004 ), while treatment with 17β-estradiol (E 2 ) or conjugated equine estrogens improves insulin sensitivity and lowers blood glucose levels ( Espeland et al . 1998 , Crespo et al . 2002 , Saglam

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Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis, and Chen Chen

type 2 diabetes (T2D). Restoration of physiological levels of insulin and GH in obesity is of particular importance to maintain healthy body composition and insulin sensitivity, as well as lipid and glucose metabolism. Sodium-glucose cotransporter 2

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Susan Kralisch, Johannes Klein, Ulrike Lossner, Matthias Bluher, Ralf Paschke, Michael Stumvoll, and Mathias Fasshauer

contrast, the adipocytokine adiponectin is downregulated in states of impaired insulin sensitivity and appears as an endogenous insulin sensitizer ( Fasshauer & Paschke 2003 ). Most recently, by using a differential display method, visfatin was

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Tomoaki Hayakawa, Tomomi Minemura, Toshiharu Onodera, Jihoon Shin, Yosuke Okuno, Atsunori Fukuhara, Michio Otsuki, and Iichiro Shimomura

.e.m. Figure 4 Effect of adipocyte MR deletion on insulin sensitivity and glucose handling. Mice fed HFHSD from 5 weeks of age underwent insulin tolerance test (ITT) 14 weeks after HFHSD feeding (A, n  = 7 in the MR flox/flox group; n  = 8 in the AdipoMR

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Haiyong Chen, Hui-Yao Lan, Dimitrios H Roukos, and William C Cho

-103/-107 in either liver or fat impaired the insulin sensitivity, and silencing of miR-103/107 in adipocytes enhanced insulin signaling, decreased adipocyte size, and enhanced insulin-stimulated glucose uptake via upregulating Caveolin-1 , a critical

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Frank H Bloomfield

), experimental studies investigating insulin sensitivity in children and young adults, which report decreased insulin sensitivity in those born preterm compared with term-born controls ( Hofman et al . 2004 , Hovi et al . 2007 , Rotteveel et al . 2008

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Li Li, Xiaohua Li, Wenjun Zhou, and Joseph L Messina

presented in A, B, and C. White gap in A, B, and C indicates grouping of lanes from different parts of the same gel. Acute psychological stress impairs glucose tolerance and insulin sensitivity We next tested whether acute psychological stress induced by IES