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Che-Pei Kung and Maureen E Murphy

underlie the role of p21/CDKN1A in the development of insulin resistance. p53 in the liver and skeletal muscle Hepatic steato­sis, or fatty liver, is one of the most common manifestations of obesity and type 2 diabetes ( Williams et al . 2013

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Carsten T Herz and Florian W Kiefer

. 2018 ). Whereas decreasing hypothalamic AMPK activity seems to confer some metabolic benefits, the loss of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through impaired brown and beige fat function ( Mottillo et al. 2016

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Paolo Comeglio, Ilaria Cellai, Tommaso Mello, Sandra Filippi, Elena Maneschi, Francesca Corcetto, Chiara Corno, Erica Sarchielli, Annamaria Morelli, Elena Rapizzi, Daniele Bani, Daniele Guasti, Gabriella Barbara Vannelli, Andrea Galli, Luciano Adorini, Mario Maggi, and Linda Vignozzi

reduced in HFD rabbits treated with INT-767, showing significantly decreased hepatic inflammation, steatosis, fibrosis and hypoxia. INT-767 effectively modulated the mRNA expression of several mediators of hepatic cholesterol uptake and metabolism and

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Victor P Bilan, Eman M Salah, Sheldon Bastacky, Huw B Jones, Rachel M Mayers, Bradley Zinker, Simon M Poucher, and Stevan P Tofovic

medial hypertrophy/sclerosis  Absent 10 10 – 10  Minimal – – 2** –  Mild – – 6** –  Moderate – – 1** – Heart  Microvesicular steatosis  Absent 10 5 5 9  Minimal – 3 2 1  Mild – 2 2 –  Myocarditis  Absent 6 3 3 –  Minimal 4 3 4 1*  Mild – 4 2 9* Liver

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Edra London, Michelle Bloyd, and Constantine A Stratakis

activity after HFD feeding and decreased hepatic steatosis, but unlike the RIIβKO mouse, RIIαKO mice did not have marked increases in oxygen consumption that could explain the observed DIO resistance. Instead, it appears that the low, but very specific

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Silva Sütt, Emmelie Cansby, Alexandra Paul, Manoj Amrutkar, Esther Nuñez-Durán, Nagaraj M Kulkarni, Marcus Ståhlman, Jan Borén, Jurga Laurencikiene, Brian W Howell, Sven Enerbäck, and Margit Mahlapuu

hepatic lipid partitioning and progression of liver steatosis and NASH . FASEB Journal 29 1564 – 1576 . ( ) 10.1096/fj.14-264937 Amrutkar M Chursa U Kern M Nunez-Duran E Stahlman M Sutt S Boren J

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Laura B Lemke, Arlin B Rogers, Prashant R Nambiar, and James G Fox

males ( n =12) and less frequently in mice less than 1 year of age exhibited moderate-to-severe centrilobular glycogen-associated hydropic degeneration superimposed over microvesicular and macrovesicular steatosis, and several had HCC. Steatosis was

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Isabelle Leclerc, Guy A Rutter, Gargi Meur, and Nafeesa Noordeen

2010 Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice . Journal of Clinical Investigation 120 4316 – 4331 . doi:10.1172/JCI41624 . Bright RT

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Libor Vítek and Martin Haluzík

insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats . Journal of Lipid Research 51 771 – 784 . ( doi:10.1194/jlr.M001602 ) Cotillard A Kennedy SP Kong LC Prifti E Pons N Le Chatelier

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Chunyan Zhao and Karin Dahlman-Wright

needs to address that LXR activation is associated with stimulation of lipogenesis resulting in increased plasma TG levels and hepatic steatosis. Several in vivo studies have shown that rodents treated with T0901317 have massive TG accumulation in the