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Martha Lappas

expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes . Gynecological Endocrinology 28 841 – 844 . ( doi:10.3109/09513590.2012.683055 ) Kvarnhammar et al. 2013 Kvarnhammar AM Tengroth

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Simon J Dunmore and James E P Brown

gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells . Diabetes 54 3410 – 3417 . ( doi:10.2337/diabetes.54.12.3410 ) Leahy JL Hirsch IB Peterson KA Schneider D 2010 Targeting β-cell function

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Rajat Kumar Das, Sarmistha Banerjee, and Bernard H Shapiro

contradiction with the accompanying ∼90% decline in CYP2C11 mRNA and protein. However, the episodic GH/JAK2/STAT5B signal transduction pathway is negatively regulated by tyrosine phosphatases ( Frank 2001 , Waxman & O'Connor 2006 ) and suppressors of cytokine

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Sara Yosefi, Gideon Hen, Charles I Rosenblum, David J Cerasale, Michaël Beaulieu, Francois Criscuolo, and Miriam Friedman-Einat

Klingenspor M 2004 Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus , is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression . Endocrinology 145 1185 – 1193 doi:10.1210/en

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Christophe Breton

activates the expression of suppressors of cytokine signalling 3 (SOCS3) that in turn inhibits leptin-induced tyrosine phosphorylation of JAK2 and STAT3 activation (indicated in red). The direct cross talk between insulin and leptin signalling at the level

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E Oliveira, C R Pinheiro, A P Santos-Silva, I H Trevenzoli, Y Abreu-Villaça, J F Nogueira Neto, A M Reis, M C F Passos, E G Moura, and P C Lisboa

-desensitization between leptin and prolactin signaling pathways despite the induction of suppressor of cytokine signaling 3 and PTP-1B . Journal of Endocrinology 195 341 – 350 . Sala F Nistri A Criado M 2008 Nicotinic acetylcholine receptors of adrenal

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Marina C Muñoz, Jorge F Giani, Marcos A Mayer, Jorge E Toblli, Daniel Turyn, and Fernando P Dominici

-kappaB . Nature Medicine 11 183 – 190 . Calegari VC Alves M Picardi PK Inoue RY Franchini KG Saad MJ Velloso LA 2005 Suppressor of cytokine signaling-3 provides a novel interface in the cross-talk between angiotensin II and insulin signaling

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Júlio Cezar de Oliveira, Egberto Gaspar de Moura, Rosiane Aparecida Miranda, Ana Maria Praxedes de Moraes, Luiz Felipe Barella, Ellen Paula Santos da Conceição, Rodrigo Mello Gomes, Tatiane Aparecida Ribeiro, Ananda Malta, Isabela Peixoto Martins, Claudinéia Conationi da Silva Franco, Patrícia Cristina Lisboa, and Paulo Cezar de Freitas Mathias

(JAK2), phosphorylated-JAK2 (pJAK2), the suppressor of cytokine signaling 3 (SOCS3), androgen receptor (AR) and glucocorticoid receptor (GR) proteins in hypothalamus homogenates obtained from 60- and 120-day-old rats ( n  = 6) were measured using

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Misuzu Yamashita, Fumio Otsuka, Tomoyuki Mukai, Hiroyuki Otani, Kenichi Inagaki, Tomoko Miyoshi, Junko Goto, Masahiro Yamamura, and Hirofumi Makino

osteogenetic process. There has been recent evidence indicating that the effects of TNF-α are primarily associated with activation of MAPK signaling, which subsequently increases the activation of stress-related proteins such as NF-κB and suppressor of cytokine

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Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra, and Urszula T Iwaniec

the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in