the hypothalamus due to constitutive expression of suppressor of cytokine signaling (hypothalamic resistance) ( Bjorbaek et al . 1998 ). Delivery of leptin directly into the hypothalamus by gene therapy normalizes body weight and extends lifespan in
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Russell T Turner, Michael Dube, Adam J Branscum, Carmen P Wong, Dawn A Olson, Xiaoying Zhong, Mercedes F Kweh, Iske V Larkin, Thomas J Wronski, Clifford J Rosen, Satya P Kalra, and Urszula T Iwaniec
Susan Kralisch, Anke Tönjes, Kerstin Krause, Judit Richter, Ulrike Lossner, Peter Kovacs, Thomas Ebert, Matthias Blüher, Michael Stumvoll, and Mathias Fasshauer
. FGF21-mediated suppression of STAT5 is accompanied by decreases in the expression of its target genes including IGF1 ( Inagaki et al . 2008 ). Furthermore, FGF21 induces hepatic expression of IGF1 binding protein 1 and suppressor of cytokine signaling
Barbara C Fam, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, and Sofianos Andrikopoulos
neuropeptide Y ( Npy ) and agouti related peptide ( Agrp ) and in the appetite-suppressing melanocortin pathway ( Huang et al . 2003 a , b ) were the predominant contributors, whereas other authors showed changes only in the suppressor of cytokine signalling 3
M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum, and V White
.placenta.2009.01.004 ) Vila L Roglans N Alegret M Sanchez RM Vazquez-Carrera M Laguna JC 2008 Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the
Christopher M Mulligan and Jacob E Friedman
suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance . Diabetes Care 32 2281 – 2287 . ( doi:10.2337/dbib9-0979 ) Ghanim H Sia CL Upadhyay M Korzeniewski K
Misuzu Yamashita, Fumio Otsuka, Tomoyuki Mukai, Hiroyuki Otani, Kenichi Inagaki, Tomoko Miyoshi, Junko Goto, Masahiro Yamamura, and Hirofumi Makino
osteogenetic process. There has been recent evidence indicating that the effects of TNF-α are primarily associated with activation of MAPK signaling, which subsequently increases the activation of stress-related proteins such as NF-κB and suppressor of cytokine
Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, and Lucila L K Elias
Stereotaxic Coordinates . San Diego, CA, USA : Academic Press . Peiser C McGregor GP Lang RE 2000 Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats . Life Sciences 67 . ( https://doi.org/10
Júlio Cezar de Oliveira, Egberto Gaspar de Moura, Rosiane Aparecida Miranda, Ana Maria Praxedes de Moraes, Luiz Felipe Barella, Ellen Paula Santos da Conceição, Rodrigo Mello Gomes, Tatiane Aparecida Ribeiro, Ananda Malta, Isabela Peixoto Martins, Claudinéia Conationi da Silva Franco, Patrícia Cristina Lisboa, and Paulo Cezar de Freitas Mathias
(JAK2), phosphorylated-JAK2 (pJAK2), the suppressor of cytokine signaling 3 (SOCS3), androgen receptor (AR) and glucocorticoid receptor (GR) proteins in hypothalamus homogenates obtained from 60- and 120-day-old rats ( n = 6) were measured using
Marina C Muñoz, Jorge F Giani, Marcos A Mayer, Jorge E Toblli, Daniel Turyn, and Fernando P Dominici
-kappaB . Nature Medicine 11 183 – 190 . Calegari VC Alves M Picardi PK Inoue RY Franchini KG Saad MJ Velloso LA 2005 Suppressor of cytokine signaling-3 provides a novel interface in the cross-talk between angiotensin II and insulin signaling
Johanna G Miquet, Lorena González, Marina N Matos, Christina E Hansen, Audreen Louis, Andrzej Bartke, Daniel Turyn, and Ana I Sotelo
family of suppressors of cytokine-signaling (SOCS) proteins, which is involved in targeting receptor complexes for internalization and signal termination and was also reported to compete with STAT5b for binding sites in GHR ( Ram & Waxman 2000 , Landsman
