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Nicolás Gigena, Vanina A Alamino, María del Mar Montesinos, Magalí Nazar, Ruy A Louzada, Simone M Wajner, Ana L Maia, Ana M Masini-Repiso, Denise P Carvalho, Graciela A Cremaschi, and Claudia G Pellizas

. We next attempted to further characterize the process of TH transport at DC level. We assessed [ 125 I]T 3 and [ 125 I]T 4 (1 nM) uptake by iDCs, as previously reported ( Visser et al . 2009 ). Time course analysis demonstrated that both THs were

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John-Paul Fuller-Jackson and Belinda A Henry

.2002) Jackson RS Creemers JWM Ohagi S Raffin-Sanson M-L Sanders L Montague CT Hutton JC O’Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene . Nature Genetics 16 303 . ( https

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Y Takei, H Hashimoto, K Inoue, T Osaki, K Yoshizawa-Kumagaye, M Tsunemi, T X Watanabe, M Ogoshi, N Minamino, and Y Ueta

amino acid from Ser to Phe in the mature sequence. As both types of cDNAs occurred in equal numbers, they may originate from two haploid genomes of parents. Prohormone excluding a putative signal peptide consists of only 91 amino acid residues, and

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N Govoni, R De Iasio, C Cocco, A Parmeggiani, G Galeati, U Pagotto, C Brancia, M Spinaci, C Tamanini, R Pasquali, G-L Ferri, and E Seren

in feeding regulation ( Nakazato et al. 2001 ). Ghrelin is synthesized as a prohormone, which is then proteolytically processed to yield a 28-amino acid peptide. A unique modification is imposed on the hormone during biosynthesis in the form

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Linda Ahlkvist, Bilal Omar, Anders Valeur, Keld Fosgerau, and Bo Ahrén

diluted 1:200. Fluorescence images were captured with an Olympus DP72 microscope and processed with CellSens dimension software. β-cell mass was determined by measuring the insulin-positive area per islet and islet size was assessed by determination of

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Charlotte van Noord, Wendy M van der Deure, Miriam C J M Sturkenboom, Sabine M J M Straus, Albert Hofman, Theo J Visser, Jan A Kors, Jacqueline C M Witteman, and Bruno H Ch Stricker

population. Assessment of thyroid status At baseline, non-fasting serum samples were obtained, which were put on ice directly and processed within 30 min after which they were kept frozen at −20 °C. TSH levels were measured with TSH Lumitest (Henning, Berlin

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Stephen C Harmer, David J Pepper, Katy Cooke, Hugh P J Bennett, and Andrew B Bicknell

Journal 379 11 – 22 . Zhou A Bloomquist BT Mains RE 1993 The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing . Journal of Biological

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Bogdan A Danalache, Calvin Yu, Jolanta Gutkowska, and Marek Jankowski

) Mitchell BF Fang X Wong S 1998 Oxytocin: a paracrine hormone in the regulation of parturition? Reviews of Reproduction 3 113 – 122 . ( doi:10.1530/ror.0.0030113 ) Morris M Castro M Rose JC 1992 Alterations in oxytocin prohormone processing

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Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani

feedback mediated by the hypothalamic–pituitary–thyroid (HPT) axis and centrally regulated by TRH ( Fig. 3 ). TRH is synthesized as a prohormone in the paraventricular nucleus (PVN) of the hypothalamus and matures into the TRH tripeptide amide (pGlu

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Gideon Hen, Sara Yosefi, Victoria Simchaev, Dmitry Shinder, Victor J Hruby, and Miriam Friedman-Einat

kinds of endoproteases, the prohormone convertase 1 (PC1, also called PC3), which generates adrenocorticotropic hormone (ACTH) from POMC and the prohormone convertase 2 (PC2), which cleaves ACTH and other parts of POMC to produce α-, β-, and γ