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John Henderson Department of Physiology, Department of Basic Medical Science, St Georges Hospital Medical School, Tooting, London SW17 0RE, UK

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One hundred years ago Ernest Starling (1866–1927), almost surreptitiously, slipped the word ‘hormone’ into the English language. This review, beginning in the middle of the nineteenth century, attempts to trace the growth of ideas in endocrinology up to this important moment.

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