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SUMMARY
Vitamins B2 and B6 are shown to have oestrogen-like effects and to act synergistically with oestradiol, increasing its action on the uterine weight of ovariectomized rats. Vitamins B1 and pantothenic acid enhanced the action of oestradiol but had no oestrogenic action themselves. Vitamin B12 had neither an oestrogen-like effect nor an influence on the action of oestradiol.
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The oestrogenic effect of Glycyrrhiza glabra extract and Pimpinella anisum oil was tested in ovariectomized mice and rats by the vaginal smear technique, and in immature rabbits or ovariectomized rats by the uterine weight method. For the first procedure the animals were injected in the morning and evening of 2 consecutive days. Four smears were taken: the first in the evening of the day after the last injection, the second and third in the morning and evening of the day after, and the fourth in the morning of the following day. Smears were regarded as positive when epithelial cornification and a decrease in the number of leucocytes could be demonstrated. The oestrogenic effect of these substances on the vagina was compared with that of a standard dose of oestradiol. The results were evaluated by the methods of Robson (1938a, b). To examine the effect on uterine development, immature and
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The inhibition of the vaginal action of oestradiol and several synthetic oestrogens by progesterone, methyl testosterone and testosterone propionate have been studied quantitatively.
The action of the natural oestrogen is more easily inhibited than that of the synthetic oestrogens.
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The effects of sodium oestrone sulphate on the uterus of the mouse in vitro have been investigated.
Motor effects are produced on the uterus of (1) oestrous animals and (2) ovariectomized animals treated with oestradiol and certain other steroids. Inhibitory effects are produced on the uterus of (1) metoestrous animals, (2) pregnant animals and (3) ovariectomized animals treated with progesterone, testosterone and certain other steroids. The antagonism between oestradiol on the one hand, and progesterone and testosterone on the other, has been studied.
Steroids which produce a condition of the uterus in which it is inhibited by sodium oestrone sulphate also inhibit the vaginal response to oestrogen in ovariectomized mice.
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In view of the widespread use of pomegranate seeds for therapeutic purposes it was decided to study the oestrogenic activity of pomegranate seed oil, which has not been investigated previously.
The oestrogenic effect of the oil was tested in immature rabbits by the uterine weight method and in ovariectomized mice by the vaginal smear technique. The results were evaluated by the method of Robson (1938). Immature rabbits were injected with the pomegranate seed oil daily for 10 days, killed without anaesthesia and their uteri weighed. Mature albino mice, weighing about 35g. were ovariectomized, injected with the oil in the morning and evening of two consecutive days. Four smears were taken: the first in the evening of the day after the last injection, the second and third in the morning and evening of the day after, and the 4th in the morning of the following day. Smears were regarded as positive
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The effects of disodium oestradiol disulphate, sodium oestrone sulphate, testosterone sulphate and strophanthin on the mouse, rabbit, rat and human uterus in vitro have been investigated. All the sex hormone derivatives produced qualitatively similar effects which appear to depend on the hormonal environment of the uterus. Strophanthin consistently produced a motor effect.
