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There is little information on the effect of sex hormones on thyroid function in infra-human primate species. We have investigated the effect of prolonged oestrogen treatment on thyroid function in adult male rhesus monkeys (Macaca mulatta), and the recovery of the gland after the treatment had ceased.
Nineteen adult male rhesus monkeys, weighing 9–10 kg., were maintained at 75 ± 2° f under uniform conditions. They received oestradiol dipropionate (2·5 mg. in 0·5 ml. sterile olive oil) i.m. twice weekly for 42 days, and thereafter once weekly up to 140 days. Controls were injected with solvent. The monkeys were killed 0, 7 and 60 days after the injections had ceased. A day before killing each animal received a single s.c. injection of propylthiouracil (20 mg.) followed by 20 μc of Na131I by the same route 1 hr. later. Each thyroid was dissected out and weighed, hydrolysed with 3%
Search for other papers by J. N. KARKUN in
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Search for other papers by B. MUKERJI in
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SUMMARY
Prolonged intramuscular injections of adrenocorticotrophic hormone (ACTH) into kittens cause marked hypertrophy of the basophil cells of the pars intermedia and cytological changes resembling the hyaline changes described in the same cells of the pars distalis. These changes indicate an altered physiological state of the basophils and probably an enhanced output of intermedin. The lack of response of the basophil cells of the pars distalis or of other cells of the pars intermedia suggests that the basophils of the two hypophysial components are physiologically dissimilar, and those of the pars intermedia are solely responsible for the elaboration of intermedin.
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Search for other papers by AMIYA B. KAR in
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SUMMARY
Sodium and potassium levels were determined in the rat endometrium and uterine washings during normal and 'delayed' implantation. Both endometrium and uterine washings of normal rats differed from those of 'delayed' animals in their electrolyte concentrations. A dose of oestradiol dipropionate (1 μg/rat) capable of inducing implantation in 'delayed' rats (ovariectomized and maintained on progesterone) did not evoke any significant changes in electrolyte concentration of either the endometrium or uterine washings. These findings are discussed in the light of a hypothesis regarding delayed implantation in rats.
