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Recent investigations suggest that age is an important factor affecting the metabolic response to injected hormones (Desaulles, 1958; Giarnieri & Lumia, 1961; Harding, Rosen & Nichol, 1961). Some of the most marked changes occur in the first few weeks of life (Barnabei, Romano, Bitonto, Tomasi & Sereni, 1966). For example, the pattern of excretion of ions and water in response to glucocorticoid administration differs markedly between the twenty-third and thirty-third day of postnatal life (Krěcěk, Dlouhá, Jelínek, Křečkova & Vacek, 1958). This variation in response may be related to differences either in target tissue sensitivity or in the concentration of circulating, biologically-effective glucocorticoids after injection (see Bellamy, 1967). The present preliminary report indicates that the age-dependent sensitivity to corticosteroids is not confined to the processes concerned with water and electrolyte balance.
Daily injections of cortisol over a dose range of 1·25–6·5 mg./100 g. initial body weight, inhibited growth in 21-day-old
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SUMMARY
Treatment of male rats with a single injection of cortisol altered the daily rhythm of weight gain and loss within 12 hr. of the injection, resulting in a net loss of weight after 24 hr. In addition, alterations in skeletal muscle composition and metabolism were studied, especially the changes with time in muscle glycogen content and O2 consumption. Glycogen deposition was detected before the increase in muscle respiration and both effects were maintained when the total amount of muscle steroid had fallen well below the initial value. It is suggested that cortisol has a releasing effect on muscle.
