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Search for other papers by M. J. BAUM in
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Search for other papers by D. A. GOLDFOOT in
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SUMMARY
Sexually immature male ferrets received electrolytic lesions in the rostral mediobasal hypothalamus, and another group of males received sham operations. Testicular size, as estimated by weekly palpation, increased rapidly after the placement of lesions. Four weeks after the operation the right testis and epididymis were found to weigh significantly more in lesioned than in sham-operated animals, whereas body weight was the same in the two groups. The right testis of lesioned ferrets had a significantly higher Leydig cell index as well as significantly larger luminal and outer diameters of the seminiferous tubules. In addition, histological examination and classification of the seminiferous tubules showed that spermatogenesis was advanced in lesioned ferrets, with pachytene spermatocytes being the most advanced germ-cell type present in a significantly higher percentage of tubules, and spermatogonia being the most advanced germ-cell type present in a significantly lower percentage of tubules. Finally, at this time the concentration of testosterone per testis was significantly higher in lesioned than in sham-operated ferrets. When the remaining testis was biopsied 20 weeks after the operation it was found that spermatogenesis was still more advanced and the concentration of testosterone in blood was significantly higher in lesioned ferrets. By the time autopsy was performed 38 weeks after the operation, all parameters of testicular function in the sham-operated male ferrets had caught up with those of lesioned animals.
In a second experiment it was found that hypothalamic lesions accelerated testicular growth without interfering with the subsequent occurrence of an annual regression and recrudescence of the testes.
Search for other papers by D. A. GOLDFOOT in
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Search for other papers by R. W. GOY in
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SUMMARY
Male guinea-pigs born to females injected with cyproterone acetate (CA) from day 28 to 58 of gestation developed non-tubular hypospadiac penes and stunted seminal vesicles and prostate glands. When adult animals were stimulated with exogenous or endogenous androgens, secretory failure and only minimal growth was observed in the accessory organs. The concentrations of endogenous testosterone in systemic plasma from intact CA males were not different from those in control males, but the uptake and distribution of [1,2-3H]testosterone in castrated CA males did not conform to control values. Deficiences in mounting, intromission and ejaculatory patterns were observed in CA males compared with controls. Lordosis, the primary behavioural response used as a criterion of 'feminization', was never observed in CA males even when large concentrations of oestrogens were administered. The results suggest that target organ insensitivity to testosterone in adulthood can be the result of deficient androgenic stimulation during embryological differentiation.
