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STEROID METABOLISM BY AN OESTROGEN-DEPENDENT INTERSTITIAL-CELL TUMOUR OF A RAT TESTIS

J. W. JULL

J. W. JULL
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D. McCLELLAN

D. McCLELLAN
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S. COUPEY

S. COUPEY
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SUMMARY

Steroid metabolism by a unique, transplantable, oestrogen-induced, hormone-dependent interstitial-cell tumour of a rat testis was investigated. After incubation of the minced tumour in medium without substrate the presence of 3α-androstanediol, 3-epiandrosterone and androsterone was shown. There was inconclusive evidence for the presence of smaller amounts of 3β-androstanediol, and no evidence for testosterone. [¹⁴C]Pregnenolone substrate was shown to be metabolized after 2 h to androstenedione, androsterone and a small amount of testosterone. Epi- and dehydroepiandrosterone were probably formed from [¹⁴C]pregnenolone, but were incompletely characterized.