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- Author: D. R. S. KIRBY x
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SUMMARY
Trophoblast derived from mouse eggs removed from the oviduct (tubal eggs) and transplanted to the kidney readily bring about degeneration of the adrenal X-zone in the intact female mouse. A similar amount of trophoblast from the same source was ineffective in ovariectomized mice. Trophoblast derived from transplanted uterine blastocysts, on the other hand, caused X-zone degeneration both in the intact and ovariectomized, and in prepubertally castrated males. The effect was abolished by hypophysectomy. It is suggested that trophoblast which develops from transplanted tubal eggs stimulates the pituitary to secrete a gonadotrophin which induces the interstitial ovarian tissue to secrete androgen which causes X-zone degeneration. Trophoblast from transplanted uterine blastocysts has the same effect and may additionally stimulate the secretion of adrenocorticotrophic hormone which, by direct action, would stimulate adrenal androgen production and thus produce degeneration of the X-zone.