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E. Möstl
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H. S. Choi
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E. Bamberg
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ABSTRACT

Administration of flumethasone (3·5 mg i.m.) to six cows on day 260 of pregnancy induced parturition in only one animal. In the other five cows circulating concentrations of epitestosterone and conjugated oestrogens increased to reach maximum values (epitestosterone, 13·73 ± 2·81 nmol/l; conjugated oestrogens, 33·59 ± 6·87 nmol/l) 2–3 days after treatment. Concentrations of these steroids were raised as long as the synthetic glucocorticoid was present in the circulation (as judged by depression of cortisol concentrations). After clearance of the drug, concentrations of these steroids declined to values present in the control group. Concentrations of unconjugated oestrogens were only slightly raised after flumethasone.

In contrast to the effect observed after administration on day 260, treatment on day 270 induced parturition in four of six treated animals. In these cows, mean circulating concentrations of epitestosterone, unconjugated and conjugated oestrogens increased to 9·50 ± 2·96, 9·62 ± 1·48 and 36·51 ± 4·8 nmol/l respectively to reach concentrations observed in the control group at parturition. After parturition the concentrations of epitestosterone and oestrogens declined rapidly in all groups.

J. Endocr. (1985) 105, 121–126

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E. MÖSTL
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K. MÖSTL
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H. S. CHOI
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H. K. DREIER
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W. STÖCKL
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E. BAMBERG
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The concentration of total unconjugated oestrogens in the peripheral plasma of cows increased from 2·00±0·20 (s.e.m.) ng/ml 7 days before to 3·87±0·50 ng/ml 1 day before parturition and declined to values below 0·30 ng/ml on day 2 post partum. The concentrations of androstenedione, epitestosterone and testosterone remained approximately constant at 0·90±0·10,0·92±0·08 and 0·40±0·20 ng/ml respectively during the last week of pregnancy. After parturition the concentration of the three androgens declined rapidly.

Similar to data obtained in goats we did not find a marked increase in androgen levels in the peripheral blood of cows before parturition.

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