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H. MILLER
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J. A. DURANT
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JOYCE M. COWAN
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J. M. S. KNOTT
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E. S. GARNETT
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SUMMARY

The excretion of steroid hormone metabolites was studied in normal, thyrotoxic and myxoedematous subjects. Corticosteroid excretion was increased in thyrotoxicosis and reduced in myxoedema.

In myxoedema there was also a fall of total androgen excretion due principally to a reduction of the androsterone component.

There was no change in total androgen excretion in thyrotoxic subjects, but there was a fall of aetiocholanolone excretion.

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JENNIFER D. GODDEN
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E. S. GARNETT
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I. F. SOMMERVILLE
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K. D. BAGSHAWE
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SUMMARY

Thyroid hormone binding capacity in serum was measured indirectly by a [131I]tri-iodothyronine (T3) resin uptake method in 36 patients with trophoblastic tumours.

A low [131I]T3 resin uptake (raised thyroid hormone-binding capacity) was found in approximately one-third of the patients but none showed clinical or other evidence of hypothyroidism. There was no correlation between [131I]T3 resin uptake test and gonadotrophin excretion. The results suggest that the increased thyroid-hormone binding capacity found in some patients with trophoblastic tumours may be related to oestrogen secretion and further study is required to establish this.

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