Division of Natural Sciences and Oakes College, Thimann Laboratories, University of California, Santa Cruz, California 95064, U.S.A.
(Received 6 May 1977)
The luteotrophic activity of human placental lactogen (HPL) in non-primates was demonstrated by its ability to maintain the induced decidual reaction in hypophysectomized pseudopregnant rats (Josimovich, Atwood & Goss, 1963). In the mouse, HPL has been reported to induce hyperaemia of corpora lutea of ovulation in non-parous mice (Kavocic, 1968). However, because of the design of the study, it was not possible to determine the duration of hyperaemia in those HPL-induced corpora lutea.
Ovarian isografts in male mice develop mature follicles that only rarely luteinize spontaneously. Such follicles luteinize upon the administration of luteinizing hormone (LH) and the resultant corpora lutea only show hyperaemia of function if a luteotrophic hormone is then given (Browning, 1968). The present investigation was undertaken to examine the hyperaemic response of ovarian isografts in