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Ivonne Gisèle Makom Ndifossap Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of
Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Francesca Frigerio Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Marina Casimir Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Florence Ngueguim Tsofack Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Etienne Dongo Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Pierre Kamtchouing Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Théophile Dimo Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Pierre Maechler Department of Cell Physiology and Metabolism, Animal Biology and Physiology, Organic Chemistry, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland Departments of

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Sclerocarya birrea is a plant widely used as traditional medication for the treatment of diabetes in sub-Saharan regions. However, the mechanism of action is unknown and only hypoglycaemic effects of S. birrea extract (SBE) in diabetic rats have been reported to date. Here, we tested aqueous extracts of S. birrea on insulin-secreting INS-1E cells and isolated rat islets. Following 24 h of treatment at 5 μg/ml, the extract markedly potentiated glucose-stimulated insulin secretion. Neither basal insulin release nor non-nutrient stimulation was affected. The potentiation of the secretory response at stimulatory glucose appeared after 12 h of treatment. No acute effects were observed and, at the effective concentration, SBE was safe regarding cell integrity and differentiation. The mechanism of action of the SBE was related to glucose metabolism as both ATP generation and glucose oxidation were enhanced following the 24-h treatment. In streptozotocin-induced diabetic rats, SBE administration corrected glycaemia and restored plasma insulin levels after 2 weeks of treatment. These data show direct action of S. birrea on insulin-secreting cells and favour further delineation for use of the plant in the management of diabetes.

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