Search Results
You are looking at 1 - 1 of 1 items for
- Author: Gustavo Casimiro-Lopes x
- Refine by access: All content x
Search for other papers by Daiana Araujo Santana-Oliveira in
Google Scholar
PubMed
Search for other papers by Henrique Souza-Tavares in
Google Scholar
PubMed
Search for other papers by Aline Fernandes-da-Silva in
Google Scholar
PubMed
Search for other papers by Flavia Maria Silva-Veiga in
Google Scholar
PubMed
Search for other papers by Gustavo Casimiro-Lopes in
Google Scholar
PubMed
Search for other papers by Patricia Cristina Lisboa in
Google Scholar
PubMed
Search for other papers by Carlos Alberto Mandarim-de-Lacerda in
Google Scholar
PubMed
Search for other papers by Vanessa Souza-Mello in
Google Scholar
PubMed
Gut dysbiosis impairs nonshivering thermogenesis (NST) in obesity. The antiobesogenic effects of exercise training might involve the modulation of gut microbiota and its inflammatory signals to the brown adipose tissue (BAT). This study evaluated whether high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) prevent overweight through reduced gut-derived inflammatory signals to BAT in high-fat-fed mice. Sixty male C57BL/6 mice (3 months old) comprised six experimental groups: control (C) diet group, C diet + HIIT (C-HIIT) group, C diet + MICT (C-MICT) group, high-fat (HF) diet group, HF diet + HIIT (HF-HIIT) group, and HF diet + MICT (HF-MICT) group. The protocols lasted for 10 weeks. HIIT and MICT restored body mass, mitigated glucose intolerance, and prevented hyperinsulinemia in HF-trained groups. A chronic HF diet caused dysbiosis, but HIIT and MICT prevented gut dysbiosis and preserved tight junction (TJ) gene expression. HF-HIIT and HF-MICT groups exhibited a similar pattern of goblet cell distribution, agreeing with the decreased plasma lipopolysaccharide concentrations and interscapular BAT (iBAT) Lbp-Cd14-Tlr4 expression. The lowered Nlrp3 and Il1β in the HF-HITT and HF-MICT groups complied with iBAT thermogenic capacity maintenance. This study shows reliable evidence that HIIT and MICT prevented overweight by restoring the diversity of the gut microbiota phyla and TJ gene expression, thereby reducing inflammatory signals to brown adipocytes with preserved thermogenic capacity. Both exercise modalities prevented overweight, but HIIT rescued Zo-1 and Jam-a gene expression, exerting more potent anti-inflammatory effects than MICT (reduced LPS concentrations), providing a sustained increase in thermogenesis with 78% less distance traveled.
