A study of the respiration of rat ventral prostate has been carried out with special reference to the effect of added carbohydrate and certain sex steroids.
The average Q o2 value for rat ventral prostate was 9·1. When this tissue was examined 48 hr after castration, there was a significant decrease in the average Q o2 value to 7·1. The rate of respiration remained the same in the absence and in the presence of added glucose or fructose.
A high concentration of testosterone, 50 μg/ml., inhibited the oxygen consumption of ventral prostate; oestradiol had a less pronounced effect. With lower concentrations of testosterone, such as 0·5 μg/ml. or 0·005 μg/ml., variable results were obtained, but the average Q o2 value did not differ significantly from that established for the ventral prostate alone. The addition of testosterone to the ventral prostate from castrate rats did not increase the respiration.