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H. VIERHAPPER
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W. WALDHÄUSL
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P. NOWOTNY
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The effect of ACTH on serum concentrations of LH and FSH was studied in six healthy women in the follicular phase of the menstrual cycle, in six healthy men and in six patients (five men, one woman) with adrenocortical insufficiency. In healthy women the i.v. administration of synthetic 1–24 ACTH (0·25 mg) induced a fall in serum concentrations of LH from 11·1 ± 1·2 (s.d.) to 7·8 ± 0·6 i.u./l (P < 0·005) after 30 min and to 8·2 ± 0·7 i.u./l after 60 min. Upon continuous infusion of 1–24 ACTH (0·25 mg i.v., t = 480 min) LH fell to 6·7 ± 0·9 i.u./l (P < 0·005) in healthy women and to 6·1 ± 3·7 i.u./l (basal, 8·7 ± 3·9 i.u./l) in healthy men. In patients with adrenocortical insufficiency serum concentrations of LH were unchanged by 1–24 ACTH. Serum concentrations of FSH were not altered by 1–24 ACTH in any of the three groups. It is suggested that the effect of ACTH on LH secretion in healthy women is mediated by the acute rise of endogenous cortisol concentrations.

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K. Trieb
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K. Dorfinger
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N. Neuhold
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E. Selzer
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A. Wilfing
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S. Czernin
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M. Hermann
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B. Niederle
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A. Gessl
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H. Vierhapper
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M. Freissmuth
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B. Grubeck-Loebenstein
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ABSTRACT

In the last decade, suramin has become known for its antiproliferative, differentiation-inducing effects on cells and has been successfully used in the therapy of cancer patients. The present study was undertaken to investigate the effects of suramin on normal human thyroid cells in primary monolayer culture and to analyse whether it also affected cells from thyroid carcinomas. The results show that suramin, at concentrations similar to serum levels obtainable during therapy, inhibited the proliferation of thyroid cells as well as the secretion of thyroglobulin. It suppressed the activation of adenylyl cyclase in thyroid membranes and decreased the immunogenicity of the cells by reducing their surface expression of HLA-DR and ICAM-1. Although the morphology of differentiated thyroid cells remained unaffected by suramin, morphological changes compatible with differentiation were observed in cells from undifferentiated thyroid carcinomas when suramin was added to the culture medium. In conclusion, the data demonstrate that suramin has pronounced in-vitro effects on normal and neoplastic thyroid cells. It may, therefore, also be effective in patients with thyroid cancer, for whom no other form of treatment is available.

Journal of Endocrinology (1992) 134, 505–511

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