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SUMMARY
Thirty-nine decerebrate rabbits, curarized and maintained by artificial ventilation, were used in the experiments. In a control group which received only saline intravenous infusions, arterial pressure remained virtually unchanged for 6 h after decerebration. Three other groups were used, all of which received intravenous infusions of aldosterone starting 1 h after decerebration and continuing for 5 h: in these groups the pressure 1 h after decerebration was taken as 100%. In a group of animals which received a normal diet before the acute experiment, the mean percentage pressure rise at the end of 5 h of aldosterone infusion was 20·0 ± 2·3 (s.e.m.)%. In a group whose drinking water had been replaced with 1% NaCl solution, the mean percentage pressure rise after 5 h was 29·6 ± 3·2. In a group pretreated with a low salt intake, the mean percentage pressure rise after 5 h was 10·3 ± 2·8%. These results show that intravenous infusions of aldosterone at the rate of 6 μg/kg/h can raise arterial pressure in acute experiments, and that varying the sodium intake can alter the responsiveness of the cardiovascular system to the hypertensive action of aldosterone.
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In a recent study of renal function in supposedly pregnant rabbits, much time and effort was wasted because about half the mated females failed to become pregnant. On retrospective analysis, the daily sodium excretion was different in the animals which became pregnant as compared with those which failed to become pregnant and which were presumably pseudopregnant. The main difference was apparent on day 4 after mating. We are now using sodium excretion as a simple diagnostic test of pregnancy in rabbits.
Fifteen animals were kept in metabolism cages for 20 days before mating and for the duration of the supposed pregnancy. Only eight of the 15 actually became pregnant. All the urine excreted by each animal each day was collected, its volume measured and its sodium concentration estimated by flame photometry. For each animal the mean daily excretion during the 20-day control period was defined as 100%. Figure 1 shows
