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SUMMARY
The possibility of applying the ovarian ascorbic acid depletion assay or its variants to the measurement of luteinizing hormone in human urine extracts has been investigated.
A 3 hr. i.v. technique proved the most sensitive.
The method had limitations as a clinical assay, namely: a relatively low degree of precision, toxicity of some urinary extracts and the fact that about 20 % of assays were invalid owing to a lack of parallelism.
Two of ten patients with amenorrhoea and raised gonadotrophin levels showed a relative lack of FSH as compared with the International Reference Preparation for human menopausal gonadotrophin.
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SUMMARY
Gonadotrophin excretion in 50 hypogonadal males has been investigated by the kaolin-acetone extraction method and the mouse uterus test.
Patients with panhypopituitarism had values for gonadotrophin excretion below the normal range while those thought to have gonadotrophin insufficiency not due to hypopituitarism had values either below or around the lower limit of the normal range. Patients with primary testicular failure, involving both seminiferous tubules and interstitial cells, including those of the Klinefelter syndrome type, usually had a high gonadotrophin excretion. Patients with failure of the seminiferous tubules had values within the normal range only. In patients with gynaecomastia without evidence of testicular disease, gonadotrophin excretion was usually normal.
The differentiation of abnormal levels, particularly at the lower limits, was not always clear-cut.