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J. R. Gosney
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ABSTRACT

A group of ten young adult male Wistar albino rats was exposed to hypobaric hypoxia at a barometric pressure of 380 mmHg for 28 days. After this period their testes were of smaller weight (and volume) in comparison with matched controls (1·220 vs 1·553 g; P < 0·005). Histological examination revealed degeneration and sloughing of spermatogenic cells in occasional tubules. Quantitative methods also revealed a marked difference in the volume of the testis occupied by Leydig cells. These were of a significantly smaller total volume in the hypoxic animals (0·046 vs 0·083 ml; P < 0·001) and this could not be accounted for merely by the smaller overall testicular volume.

J. Endocr. (1984) 103, 59–62

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J. R. Gosney
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PubMed
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ABSTRACT

When a group of adult male Wistar rats was exposed to a barometric pressure of 380 mmHg for 28 days in an hypobaric chamber, profound changes occurred in their hypothalamic-pituitary-thyroidal axes in comparison with normobaric controls. The thyroid glands of the hypoxic animals had an inactive appearance, comprising large colloid-filled follicles lined by low epithelium. The thyrotrophs of the pars distalis of the pituitary glands were markedly decreased in number. They occupied only 0·41% of the total cell population in contrast with 1·34% in the controls (P<0·001); a total population which is itself decreased in the hypoxic animals. Classical 'thyroidectomy cells' were not seen. These observations support previous studies which indicate suppression of thyroid function in an hypoxic environment, and tend to suggest that this is a consequence of a direct effect of hypoxia on the hypothalamus or pituitary gland, rather than on the thyroid itself.

J. Endocr. (1986) 109, 119–124

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