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Animal Reproduction Teaching and Research Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.
(Received 26 September 1974)
While it is widely recognized that androgens appear to be essential for maintenance of the spermatogenic process in a variety of scrotal mammals (Steinberger, 1971) and that ambient temperatures exceeding the thermoregulatory capabilities of the scrotum and pampiniform plexus are detrimental to sperm production, surprisingly little information is available concerning the effects of heat on the enzymology of testicular steroidogenesis (VanDemark & Free, 1970). Hall (1965) has demonstrated that incorporation of [1-14C]acetate into [14C]test-osterone by rabbit testis slices in vitro is maximal at the scrotal temperature and depressed at the abdominal temperature. The data of Le Vier & Spaziani (1968), using non-replicate experiments, suggest that testicular conversion of [4-14C] cholesterol to [14C]pregnenolone (cholesterol side-chain cleavage enzyme, CSCCE) in the rat exhibits a positive in-vitro temperature coefficient over a range of 28–36 °C
