Homotransplantation of the anterior pituitary gland of rats was made into the anterior chamber of the eye. The centre of the grafts developed ischaemic necrosis, but the peripheral zone remained alive to a depth of about 100 μ. During the next 6 weeks there was no evidence of significant regeneration or atrophy of this live peripheral zone, and mitoses were not observed there. The gradual resorption and scarring of the central necrotic area led to a diminution of the overall size of the graft.
In the surviving tissue nearly all the chromophil cells became completely degranulated during the first week or two. After 6 weeks only very rare shrunken basophil cells remained, although a few acidophil cells could still be identified.
From previous work it is known that such intraocular grafts have very little functional activity. This may possibly be because of the absence of any direct connexion between the graft and the hypothalamus, but the reduction of the total amount of parenchyma may also be an important factor.