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G. A. ROBINSON
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K. H. TAM
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SUMMARY

Counting of radioactivity in Japanese quail in vivo showed a rapid loss of 131I from the body 12–24 h after the i.v. injection of [131I]thyroxine (T4), followed by a period of slow decrease in counting rates to 96 h. From comparison of these [131I]T4 curves with curves for 131iodide-injected birds and from counts on serum and other tissues in vitro it was concluded that, for Japanese quail, the T4 secretion rate should be calculated using serum samples taken during the first 12 h. Using this time period, the parameters measured were: T4 distribution space, laying hens 45·7 and mature cocks 26·3 ml/100 g body weight; fractional degradation rate for T4, hens 5·73 and cocks 3·12/day; serum T4 concentration (Tetrasorb125 method), hens 1·20 ± 0.07 and cocks 1·34 ± 0.05 (s.e.m.)μg/100 ml (n= 16); T4 secretion rate, hens 3·14 and cocks 1·10 μg/100 g/day.

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PAMELA A. McLAUGHLIN
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G. P. NIRMALAN
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K. H. TAM
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G. A. ROBINSON
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SUMMARY

Intramuscular injection of KSCN, KClO4 or KI into laying Japanese quail resulted in the discharge of 12·6 to 34·0% of the ovarian 131I within a 1-h measurement period for birds studied 1 to 6 h after labelling. Potassium thiocyanate was as effective as an equimolar quantity of KClO4 in causing this discharge. For birds studied 18 h after labelling, no consistent effect of KClO4, KSCN or KI on ovarian 131I levels was found. Gel, thin-layer and paper chromatography of labelled oocytes determined that > 92% of the 131I was present as inorganic iodide.

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