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Functional human to mouse adipose tissue xenotransplantation

Vitaly Ablamunits

Vitaly Ablamunits
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Simon Klebanov

Simon Klebanov Department of Immunobiology, Obesity Research Center, Lenox Hill Hospital and Private Ambulatory Clinic, Yale University School of Medicine, 300 George Street, Suite 334-D, New Haven, Connecticut, USA

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Sharon Y Giese

Sharon Y Giese Department of Immunobiology, Obesity Research Center, Lenox Hill Hospital and Private Ambulatory Clinic, Yale University School of Medicine, 300 George Street, Suite 334-D, New Haven, Connecticut, USA

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Kevan C Herold

Kevan C Herold
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White adipose tissue (WAT) produces a number of metabolically important factors and, therefore, some inborn errors of metabolism may potentially be corrected by transplantation of normal allogeneic WAT. To explore the ability of human WAT (HuWAT) to compensate for a missing factor and to induce allogeneic immune response, we created leptin-deficient, immunodeficient mice and transplanted them with either 2.5 or 5 ml HuWAT. Recipient mice showed stable levels of human leptin in circulation, reduced body mass gain, and amelioration of hepatic steatosis. Food consumption and plasma insulin levels were reduced only in recipients of 5 ml WAT. Transfer of 2×10⁷ human mononuclear cells to reject WAT as an allograft was ineffective and resulted only in some reduction of circulating leptin and a limited damage to the WAT grafts followed by the loss of human leukocytes.