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*Department of Biochemistry, †Department of Obstetrics and Gynaecology, Program in Reproductive Biology and ‡Department of Pathology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada L8S 4J9
(Received 28 May 1974)
Although (−)-trans-Δ9-tetrahydrocannabinol (THC), the major psychoactive constituent of marihuana (Mechoulam & Shani, 1970), has a wide variety of pharmacological actions, little is known about the effects of this compound on endocrine function. Nir, Ayalon, Tsafriri, Cordova & Lindner (1973) demonstrated that administration of THC to pro-oestrous rats resulted in suppression of the pre-ovulatory surge of luteinizing hormone. Kolodny, Masters, Kolodner & Toro (1974) have found depressed plasma testosterone levels in marihuana smokers. Gynaecomastia in chronic marihuana smokers has been reported (Harmon & Aliapoulos, 1972) and intimated to result from an effect of THC on prolactin (PRL) secretion. Since oestradiol-17β benzoate (OB) is known to affect PRL release (Chen & Meites, 1970), the present work was undertaken to examine the hypothesis
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SUMMARY
The milk-ejecting potencies of deamino-oxytocin and oxytocin were compared by means of recordings of intramammary pressure in lactating women.
No difference in milk-ejecting potency was found between the two peptides in one woman 16 months after delivery; at this time her blood did not inactivate either of the peptides.
In other women on the third day post partum, deamino-oxytocin was found to be 1·5 times as potent as oxytocin (w/w). At this stage, the blood of the patients inactivated oxytocin (half life: 10 min.) but not deamino-oxytocin; this effect accounts only in part for the difference in potency between the two peptides.
