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DECREASE IN HUMAN PLASMA PROLACTIN LEVELS BY ORAL PROSTAGLANDIN E₂ IN EARLY PUERPERIUM

F. CAMINITI

F. CAMINITI
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M. DE MURTAS

M. DE MURTAS
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G. PARODO

G. PARODO
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U. LECCA

U. LECCA
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A. NASI

A. NASI
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Eight milligrams of prostaglandin E₂ (PGE₂; 2 mg every 30 min) were given orally to 12 puerperal women on day 4 after delivery. Plasma levels of prolactin showed a significant decrease in comparison with basal levels and with those of controls sampled over a similar period. The same dose of PGE₂ was ineffective in modifying the plasma prolactin levels in four puerperal women on day 30 after delivery and in four non-pregnant women with normal levels of prolactin. It is suggested that a PGE₂-induced decrease in prolactin could be mediated by hypothalamic dopaminergic neurones.