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F. CAVAGNINI and M. PERACCHI

SUMMARY

The effect of reserpine on growth hormone (GH) secretion induced by insulin hypoglycaemia and by arginine infusion was studied in ten normal subjects and ten hyperthyroid patients. In both groups of subjects, oral reserpine administration resulted in a reduction of GH response to hypoglycaemia, but caused no significant change of GH release after arginine infusion. These results strongly support the theory of an adrenergic control of GH secretion and indicate that arginine stimulates GH secretion in a different way from insulin and independently of catecholamines.

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F. CAVAGNINI, M. PERACCHI, G. SCOTTI, U. RAGGI, A. E. PONTIROLI and R. BANA

SUMMARY

The effect of both oral and intravenous administration of l-DOPA on growth hormone (GH) secretion was studied in a group of normal volunteers: a significant rise of serum GH levels was observed in both cases.

Growth hormone release in response to insulin hypoglycaemia and to arginine infusion was evaluated in a group of Parkinsonian patients before and after 25 days' treatment with l-DOPA plus a DOPA-decarboxylase inhibitor. In addition, GH response to the above stimuli was studied in a group of patients who had been under treatment for more than 6 months with l-DOPA alone. In untreated Parkinsonian patients, GH response to insulin hypoglycaemia was at the lower limit of normal range while arginine-induced GH release was significantly reduced. Treatment with l-DOPA did not increase GH responses. Some possible interpretations of the results are discussed.

The findings support the possibility that dopamine plays a role in the physiological regulation of GH secretion, as in the case of luteinizing hormone, follicle-stimulating hormone and prolactin release.