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E. Aguilar, M. L. Rodríguez-Padilla, and L. Pinilla


Prolactin has been involved in different types of hypertension both in man and in rats. In an attempt to substantiate this hypothesis, we have analysed the correlation between plasma concentrations of prolactin and systolic blood pressure (SBP) in female and male rats from spontaneously hypertensive (SH) and normotensive Wistar–Kyoto strains (30, 60 and 90 days old), as well as in adult female Wistar rats rendered hyperprolactinaemic by the administration of 100 μg testosterone propionate on day 1 of life, or adult males with low plasma concentrations of prolactin after administration of bromocriptine (4 mg/kg per day) over 15 days. Our results indicate a lack of correlation between plasma concentrations of prolactin and SBP since plasma concentrations of prolactin were normal in male and female SH rats and hyper- and hypoprolactinaemia did not affect SBP.

In spite of these normal plasma concentrations of prolactin, SH rats showed subtle changes in the secretion of this hormone in vitro and in vivo in response to exogenous serotonin administration and to immobilization.

Journal of Endocrinology (1990) 125, 359–364

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M. Rodriguez-Padilla, C. Bellido, L. Pinilla, and E. Aguilar


Weights of testes, seminal vesicles, ventral prostate and pituitary, plasma testosterone and LH concentrations, pituitary LH content and concentration, the LH in-vivo response after LHRH administration (1 μg), and basal and LHRH-stimulated secretion in vitro were analysed in adult male spontaneously hypertensive (SH) and normotensive control (WKY) rats.

Spontaneously hypertensive rats showed: (1) testis and pituitary hypertrophy; (2) seminal vesicle and ventral prostate atrophy; (3) increased plasma testosterone and LH concentrations; (4) increased pituitary LH content and concentration; (5) unchanged net increase of plasma concentrations of LH 15 and 45 min after administration of 1 μg LHRH; and (6) increased basal LH secretion in vitro with a normal response to LHRH stimulation.

These results provide evidence that SH rats show increased LH secretion with a normal response to LHRH stimulation. The coexistence of high plasma concentrations of testosterone with seminal vesicle and ventral prostate atrophy suggest a reduction in the effectiveness of testosterone in these structures.

J. Endocr. (1987) 113, 255–260