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SUMMARY
The concentration of relaxin in the circulating blood of ewes has been investigated during the last 2 months of pregnancy.
When assayed on the symphysis pubis of oestrogen-primed mice, the concentration of relaxin present in extracts was less than 0·2 u./ml. serum. The extracts produced no measurable effects on weight or histology of the uterine tract or on distensibility of the cervix of oestrogen-primed mice, whether or not progesterone was also given.
It is concluded that in the sheep the amount of relaxin in the circulating blood during the later stages of gestation is too low to detect, by existing assay procedures, abnormalities in blood concentrations in conditions such as Ring Womb.
Confirmation is provided of an earlier report that the concentration of relaxin in the blood of pregnant mice during the period of rapid interpubic separation is also less than 0·2 u./ml. serum.
