Search Results

You are looking at 1 - 1 of 1 items for

  • Author: P. LIEDHOLM x
  • Refine by access: All content x
Clear All Modify Search
G. FINK
Search for other papers by G. FINK in
Google Scholar
PubMed
Close
,
G. GENNSER
Search for other papers by G. GENNSER in
Google Scholar
PubMed
Close
,
P. LIEDHOLM
Search for other papers by P. LIEDHOLM in
Google Scholar
PubMed
Close
,
J. THORELL
Search for other papers by J. THORELL in
Google Scholar
PubMed
Close
, and
J. MULDER
Search for other papers by J. MULDER in
Google Scholar
PubMed
Close

SUMMARY

The concentrations of luteinizing hormone releasing hormone (LH-RH) and luteinizing hormone (LH) were determined by radioimmunoassay in blood samples taken at intervals after the administration of different doses of synthetic LH-RH administered either intravenously or intranasally in healthy fertile men. Intranasal administration of LH-RH caused a dose-dependent increase of plasma LH with the peak occurring later than that after intravenous injection. The intravenous route was approximately 100 times more effective than the intranasal route in terms of the dose of LH-RH necessary to achieve an LH response of similar magnitude, but the route through the nasal mucosa seems a safe and convenient way for LH-RH administration. The characteristics of the disappearance curve, metabolic clearance rate and volumes of distribution of LH-RH in man are compared with those found by others.

Restricted access