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SUMMARY
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (National Institutes of Health—NIH have been incubated with varying concentrations of urea at different temperatures and for different periods of time.
The luteinizing activity of NIH-LH was destroyed to a greater extent than the follicle-stimulating activity of NIH-FSH at all concentrations of urea employed.
Higher temperatures tended to increase the degree of inactivation of both FSH and LH, while the time of incubation did not affect the results.
It is suggested that at concentrations of urea below 6 m inactivation of gonadotrophic activity is produced by ammonium cyanate formed from urea during incubation.
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SUMMARY
Human chorionic gonadotrophin (HCG), pregnant mare serum gonadotrophin (PMSG) and human menopausal gonadotrophin (HMG) were incubated with varying concentrations of urea at different temperatures for different times.
The luteinizing hormone (LH) activity of HCG was progressively destroyed with increasing concentrations of urea. The degree of inactivation was greater at higher temperatures but the time of incubation did not affect the results.
The follicle-stimulating activity of PMSG was reduced at high urea concentrations; the time of incubation was without effect.
Under the experimental conditions used the LH activity of HMG was generally destroyed to a greater extent than its follicle-stimulating hormone activity.
