Search Results
You are looking at 1 - 1 of 1 items for
- Author: Q Xiao x
- Refine by access: All content x
Search for other papers by Q Xiao in
Google Scholar
PubMed
Search for other papers by X Han in
Google Scholar
PubMed
Search for other papers by E Arany in
Google Scholar
PubMed
Search for other papers by D Hill in
Google Scholar
PubMed
Search for other papers by Challis JR in
Google Scholar
PubMed
Search for other papers by TJ McDonald in
Google Scholar
PubMed
Extracts of human term amniotic, placental, and chorion/decidua tissue contained, respectively, 4.36 +/- 2.79 (pmol/g wet wt; mean +/- S.E.M.: n = 5). 2.78 +/- 0.5 (n = 5) and 0.68 +/- 0.68 (n = 5) peptide YY (PYY)-like immunoreactivity. Using a specific PYY antiserum, gel filtration chromatography and reverse-phase high performance liquid chromatography (HLPC), amniotic, placental and fetal intestinal tissue extracts were demonstrated to contain PYY-like immunoreactivity consisting of equal amounts of PYY1-36 and PYY3-36. The presence of pancreatic polypeptide was not detected in any of the extracts. Positive immunohistochemical staining for PYY was seen in extravillous trophoblasts in the decidual septa and fetal membranes, the syncytiotrophoblast and cytotrophoblasts, amniotic epithelial cells and in maternal decidual stromal cells. Positive staining for PYY was found at the earliest date examined (9.5 weeks) and remained present throughout pregnancy to term. PYY1-36 and PYY3-36 may play important roles in human pregnancy, acting via endocrine or paracrine mechanisms.
