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- Author: R. A. DALE x
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SUMMARY
1. The urinary sodium output in adrenalectomized rats maintained on DCA and cortisone varies closely with the intake of sodium, in spite of a constant level of hormone administration.
2. There was evidence of lack of control of body sodium and potassium at both high and low extremes of sodium intake used.
3. It is argued that the results presented are evidence of (a) extra-adrenocortical control of sodium metabolism, and (b) increased adrenocortical secretion following sudden changes in dietary sodium.
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1-Oxygenated steroids were recognized during preliminary characterization of substances isolated from the urine of two hypertensive infants (Edwards, Harvey & Knight-Jones, 1968; Edwards & Trafford, 1968) with raised values of the steroid 11-oxygenation index (Edwards, Makin & Barrett, 1964; B. E. Clayton, R. W. H. Edwards & H. L. J. Makin, in preparation). Shortly afterwards, Gower, Daly, Snodgrass & Stern (1970) described a 15-month-old female child with a virilizing adrenocortical carcinoma, who was excreting large quantities of dehydroepiandrosterone and monofunctional C19-Δ16-steroids together with increased quantities of testosterone, oestrogens and pregnanediol. Since this child was also hypertensive (blood pressure ranged from 160/85 to 180/115 mmHg) and had a urinary steroid 11-oxygenation index of 1·3 (upper limit of normal 0·7 at the 90% level) it was decided to look for 1-oxygenated steroids in her urine.
Examination of qualitative, two-dimensional paper chromatograms (Edwards, 1968) of urinary extracts with the