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Program in Reproductive Biology and Endocrinology, University of Texas Medical School at Houston, Houston, Texas 77025, U.S.A.
(Received 21 May 1974)
The atrophy of testes and sex accessories in adult male rats, associated with a decrease in pituitary gonadotrophin levels after oestrogen administration, is well established (Greep, 1961; Price & Williams-Ashman, 1961). Since gonadotrophins stimulate androgen production and secretion by the testes, atrophy of the sex accessory organs in oestrogen-treated animals is attributed to diminished testosterone production, secondary to low levels of luteinizing hormone (LH) in the blood (Moore & Price, 1932). However, recent studies have shown that oestrogen administration for relatively short periods of time causes a decrease in the sex accessory weights but the serum LH levels remain unchanged (Mallampati & Johnson, 1973; Chowdhury, Tcholakian & Steinberger, 1974). In addition, the oestrogen treatment produces a rapid decrease in testicular (Chowdhury et al. 1974) and plasma (Danutra, Harper, Boyns,
