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GILLIAN D. BRYANT
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R. M. CONNAN
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F. C. GREENWOOD
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Considerable indirect evidence exists that certain drugs, including phenothiazine derivatives, stimulate the release of prolactin from the anterior pituitary (see review by Meites, Nicoll & Talwalker, 1963). As a direct test of this hypothesis a radioimmunoassay for sheep prolactin (Bryant & Greenwood, 1968) was used to measure plasma prolactin levels after the i.m. or i.v. injection of acepromazine in eight sheep of the Clun Forest breed (Table 1). Evidence for the specificity of the plasma prolactin measurements has been adduced (Bryant & Greenwood, 1968). Nevertheless prolactin concentration in plasma has been expressed in terms of the weight of the reference standard preparation (NIH-P-S 6). If biological and immunological measurements were identical, the levels of plasma prolactin of 50–500 ng./ml. obtained here would be equivalent to 1·25–12·5 m-u./ml.

The four female sheep investigated formed part of a study relating the degree of parasitic infestation with the reproductive cycle (Connan, 1968), and

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