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Department of Medicine and Biochemistry Research Group, University of Otago Medical School, Dunedin, New Zealand
(Received 7 October 1974)
High doses of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) inhibit bone mineralization, induce hypercalcaemia and diminish intestinal absorption of calcium in the rat (Gasser, Morgan, Fleisch & Richelle, 1973; Goulding & McChesney, 1974). This hypercalcaemia, either by a direct effect or by inhibiting secretion of parathyroid hormone (PTH), may suppress renal synthesis of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) and hence explain the diminished intestinal absorption of calcium (Bonjour, DeLuca, Fleisch, Trechsel, Matejowee & Omdahl, 1973; Hill, Lumb, Mawer & Stanbury, 1973). Parathyroid hormone affects the renal production and excretion of cyclic AMP (Chase & Aurbach, 1967) and cyclic AMP enhances the synthesis of 1,25(OH)2D3 (Rasmussen, Wong, Bikle & Goodman, 1972; Larkins, MacAuley, Rapoport, Martin, Tullock, Byfield, Matthews & Maclntyre, 1974). Thus reduced production of cyclic AMP after administration of EHDP may be important in diminishing renal synthesis
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Changes in urinary hydroxyproline excretion reflect changes in bone resorption (Rasmussen, 1971). High urinary hydroxyproline excretion occurs in primary hyperparathyroidism and after administration of exogenous parathyroid hormone (Prockop & Kivirikko, 1967). However, the urinary excretion of hydroxyproline is not necessarily raised in uraemic patients despite increased secretion of parathyroid hormone, possibly because of abnormal synthesis or maturation of bone collagen (Dubovsky, Dubovska, Pacovsky & Hrba, 1968; Constantinides, Kostamis, Ktoros & Malamos, 1970; Jaworski, Paulsen, Couture, Posen & Galus, 1972).
An experiment was undertaken to determine whether removing the parathyroid glands would affect the urinary excretion of hydroxyproline by uraemic animals. Male Wistar rats (100–120 g) were sham-operated on (groups A and C) or were made uraemic (groups B and D) by first removing two-thirds of the right kidney by cautery and 1 week later removing the entire left kidney. Animals in groups C and D were parathyroidectomized (PTX) immediately before
