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SUMMARY
The steroidogenic effect of histamine in isolated adrenocortical cells of the dog was investigated in the presence of prostaglandin E2 (PGE2) and/or dibutyryl cyclic AMP (dbcAMP) in the medium. The effect of histamine, in combination with PGE2, was less than their total individual effects in the production of cortisol, but not of corticosterone. With dbcAMP the effect was just equal to them. However, the combination of histamine, PGE2 and dbcAMP showed an increase twice that of their total individual effects in the production of both steroids. These results indicate that, in the dog, histamine, PGE2 and dbcAMP may act synergistically in the adrenocortical cells.
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Department of Physiology, Nagasaki University School of Medicine, Nagasaki, Japan
(Received 2 September 1977)
In the dog, intravenous injection of histamine produces a marked increase in adrenocortical secretion (Suzuki, Hirai, Yoshio, Kurouji & Yamashita, 1963; Papp, Stark, Ács & Varga, 1964; Asano, 1966; Katsuki, Ito, Watanabe, lino, Yuji & Kondo, 1967; Tanigawa, 1967; Narita, 1971; Yamashita, Shimizu, Mieno & Kawao, 1973; Hirose, Matsumoto & Suzuki, 1976; Hirose, Matsumoto, Aikawa & Suzuki, 1977). The adrenocortical response of the dog to histamine was found to be markedly reduced, although not completely eliminated, by hypophysectomy (Hirose et al. 1976, 1977). This indicates that the response, although dependent for the main part on the pituitary gland, may involve a direct effect of histamine on the adrenal cortex or some other extrapituitary factor. In the present study, a direct stimulatory effect of histamine on the adrenal cortex was examined by evaluating the production of cortisol
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Department of Physiology, Nagasaki University School of Medicine, Nagasaki, Japan
(Received 5 January 1977)
A systemic administration of histamine to intact dogs markedly increases the adrenocortical secretion (Suzuki, Hirai, Yoshio, Kurouji & Yamashita, 1963; Papp, Stark, Acs & Varga, 1964; Asano, 1966; Katsuki, Ito, Watanabe, Iino, Yuji & Kondo, 1967; Tanigawa, 1967; Yamashita, Shimizu, Mieno & Kawao, 1973). This effect was found to be completely abolished by hypophysectomy (Asano, 1966). In the experiments by Tanigawa (1967), however, a slight increase in adrenocortical secretion in response to histamine was observed in some hypophysectomized dogs. In the present work a direct adrenocortical stimulatory effect of histamine was examined by evaluating the adrenal secretion of cortisol and corticosterone in response to histamine in hypophysectomized dogs.
Thirteen mongrel male dogs weighing 10·0–16·8 kg were used; four of them were intact, and the others were hypophysectomized. Under sodium pentobarbitone (25 mg/kg, i.v.) anaesthesia, hypophysectomy was