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SUMMARY
1. Daily oral administration of between 0·1 and 0·5 mg. quinestradol (3-cyclopentyl ether of oestriol) for 14 days to four spayed monkeys induced macroscopic uterine haemorrhage in three and microscopic bleeding in the fourth. This is in marked contrast to the finding that in women this compound seems to act only on the lower genital tract and does not cause uterine withdrawal bleeding.
Oestriol, given in the same way at a daily dosage of 0·82 mg., also induced withdrawal bleeding in one monkey.
2. The urinary excretion of quinestradol and oestriol was studied in two of the monkeys and that of quinestradol alone in a post-menopausal woman. The findings indicate that some quinestradol is excreted as oestriol, which in monkeys, unlike women, appears to be unconjugated.
3. Possible reasons for the observed differences in the biological effects of quinestradol in the two species are briefly discussed.
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SUMMARY
The uptake of technetium-99m (99mTc) by the thyroid was measured 15 min after injection using a directional counting technique. The 'washout' of thyroidal 99mTc after intravenous perchlorate injection was quantitated so that separate measurement of the extrathyroidal activity of 99mTc was unnecessary.
In normal subjects the thyroidal uptake was 1·28 ± 0·61% of the administered dose (mean ± 1 s.d.); in primary myxoedema 0·26 ± 0·28%, in simple goitre 2·18 ± 2·10%, in thyrotoxicosis 11·0 ± 5·4%, in hypothyroid patients with Hashimoto's disease 4·50 ± 3·70% and in three patients with Pendred's syndrome the mean uptake was 9·3%.
The technique has been evaluated and its advantages as a simple alternative to quantitative scintiscanning are discussed.
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The rise in plasma corticosteroid concentration after the administration of corticotrophin (ACTH) is an index of the functional reserve of the adrenal cortex (Eik-Nes, Sandberg, Nelson, Tyler, & Samuels, 1954). A synthetic polypeptide β1–24 (Synacthen, Ciba) containing the amino acids 1–24 of the 39 found in pituitary ACTH (Kappeler & Schwyzer, 1961) is as active in stimulating the adrenal as corticotrophin (Landon, James, Cryer, Wynn & Frankland, 1964; Ohlsen & Hökfelt, 1965; Wood, Frankland, James & Landon, 1965). Wood et al. (1965) have shown that the rise in plasma corticosteroids (Mattingly, 1962) 30 min. after the i.m. administration of 250 μg. Synacthen can be used as a measure of adrenocortical reserve. We report our experience with this test carried out between 8 a.m. and 10 a.m. in two groups of hospital patients.
Group I comprised 21 women and nine men, aged from 20 to 73 yr. (mean age 46
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The association of endemic goitre with 'hard water' has been recognized for many years (see Murray, Ryle, Simpson & Wilson, 1948). Since radioactive iodine is such a useful tool in the investigation of thyroid physiology it is surprising that the effects of calcium on the function of the normal thyroid gland in man have not been studied with isotopic techniques. Studies of thyroid function with 132I on volunteers with dietary calcium supplements during 6 weeks are therefore reported.
Six euthyroid subjects without a goitre were investigated. Five received 1·9 g. calcium daily in five divided doses as effervescent Calcium Sandoz tablets dissolved in 100 ml. tap water. Each tablet contains 4 g. calcium gluconate (equivalent to 0·38 g. calcium) and 20 mg. ascorbic acid. The sixth subject received placebo tablets which did not contain calcium.
The thyroidal uptake of radioactive iodine 2½ hr. after an oral dose of 25
