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George Bikopoulos, Aurelio da Silva Pimenta, Simon C Lee, Jonathan R Lakey, Sandy D Der, Catherine B Chan, Rolando Bacis Ceddia, Michael B Wheeler and Maria Rozakis-Adcock

.1±0.12 NM_139314  Aldo-keto reductase, family 1, member B10 (AKR1B10) +1.31±0.05 +1.76±0.17 NM_020299  Methylcrotonoyl-coenzyme A carboxylase 1 (MCCC1) −0.80±0.07 −0.75±0.10 NM_020166 Cellular transport  Aquaporin 3 (AQP3) 1.26±0.11 NC NM_004925 Glycolysis

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Valerie M Harris, Sachin V Bendre, Francina Gonzalez De Los Santos, Alemu Fite, Ahmad El-Yaman El-Dandachli, Lyazat Kurenbekova, Abdul B Abou-Samra and Colleen Buggs-Saxton

subsequent infusion of glucose together with insulin restored normal GnRH pulse frequency ( Ohkura et al . 2004 ). In addition, a study using inhibitors of glycolysis showed that GnRH-stimulated release of LH was impaired ( Sen et al . 1979 , Howland 1980

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Mauricio da Silva Krause, Aline Bittencourt, Paulo Ivo Homem de Bittencourt Jr, Neville H McClenaghan, Peter R Flatt, Colin Murphy and Philip Newsholme

50 pg/ml dose did work, but the maximum physiological dose was 100 pg/ml. The significance of higher doses (to which islets still continue to respond) is under investigation. The enhancement of the ATP/ADP ratio due to increased glycolysis, glucose

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Graziela R Stoppa, Maristela Cesquini, Erika A Roman, Patrícia O Prada, Adriana S Torsoni, Talita Romanatto, Mario J Saad, Licio A Velloso and Marcio A Torsoni

known negative modulator of phosphofructokinase, a key enzyme of the glycolysis pathway. Thus, there is a link between the glycolytic pathway and the production of malonyl-CoA. Fluctuations in hypothalamic concentrations of malonyl-CoA during fasting and

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Gabriele Wolf, Nicole Aumann, Marta Michalska, Antje Bast, Jürgen Sonnemann, James F Beck, Uwe Lendeckel, Philip Newsholme and Reinhard Walther

cytosolic proteins, leading to a decrease in oxidative phosphorylation, decreased glycolysis, and consequently decreased ATP levels as well as impaired insulin secretion. The resulting mitochondrial damage promotes β cell death ( Azevedo-Martins et al

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Valentina Pampanini, Daniela Germani, Antonella Puglianiello, Jan-Bernd Stukenborg, Ahmed Reda, Iuliia Savchuk, Kristín Rós Kjartansdóttir, Stefano Cianfarani and Olle Söder

substrates. To do this, SCs internalize glucose from the interstitial space via GLUT-1 and GLUT-3 glucose transporters ( Galardo et al . 2008 ) and use it to produce lactate via glycolysis pathway. Lactate produced from SCs is the main energy source for

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Christopher M Mulligan and Jacob E Friedman

-negative bacteria ( Coveney et al . 2015 , Fensterheim et al . 2017 ). Immediately following TLR stimulation, macrophages shift their metabolic profile to one that favors glycolysis over oxidative metabolism ( Everts et al . 2014 ) promoting a pro

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Saeed Alshahrani and Mauricio Di Fulvio

-characterised mechanism whereby glucose stimulates insulin secretion is the ATP-sensitive K + (K ATP ) channel-dependent pathway. In this mechanism, glucose is transported into the β-cell and metabolised. Glycolysis and mitochondrial respiration results in increased ATP

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Smithamol Sithara, Tamsyn M Crowley, Ken Walder and Kathryn Aston-Mourney

the pancreatic beta-cell via glucose transporters where it undergoes glycolysis and signals for insulin to be secreted ( Ashcroft & Rorsman 2012 , Esguerra et al . 2014 ). However, under insulin-resistant conditions, typically associated with obesity

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Chunchun Wei, Xianhua Ma, Kai Su, Shasha Qi, Yuangang Zhu, Junjian Lin, Chenxin Wang, Rui Yang, Xiaowei Chen, Weizhong Wang and Weiping J Zhang

Horton JD Uyeda K 2004 Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis . PNAS 101 7281 – 7286 . ( https://doi.org/10.1073/pnas.0401516101 ) Jing G Chen J Xu G Shalev A